In Utero Exposure to Poly and Perfluoroalkyl Substances (PFASs) and Subsequent Breast Cancer
By Barbara A Cohn, Michele A La Merrill, Nickilou Y Krigbaum, Miaomiao Wang, June-Soo Park, Myrto Petreas, Gregory Yeh, Russell C Hovey, Lauren Zimmermann, and Piera M Cirillo
Reprod. Toxicol.
July 22, 2019
DOI: 10.1016/j.reprotox.2019.06.012
We tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9,300 daughters born 1959-1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 daughter breast cancer cases diagnosed by age 52, and 310 controls matched on birth year and blood draw trimester. High maternal N-ethyl-perfluorooctane sulfonamido acetic acid (EtFOSAA), a precursor of perfluorooctane sulfonic acid (PFOS), in combination with high maternal total cholesterol predicted a 3.6-fold increased risk of breast cancer (p<0.05). Conversely, maternal PFOS was associated with decreased breast cancer risk in daughters. Predictions were robust to alternative modeling and independent of other maternal factors. Future generations continue to be exposed to ubiquitous, persistent PFASs. If confirmed experimentally, these findings are relevant to breast cancer prevention.
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