Invited Perspective: PFAS and Dyslipidemia-The Perimenopausal Period as a Critical Time Window
By Lida Chatzi and Brittney O Baumert
Environ Health Perspect
August 8, 2023
DOI: 10.1289/EHP13195
Disturbances to hepatic lipid metabolism—a complex system contribute to the onset and progression of metabolic diseases such as metabolic syndrome, dyslipidemia, and hypertension.
Environmental exposures such as per- and polyfluoroalkyl substances (PFAS) perturb these systems by wreaking havoc on metabolic processes. Previous studies have demonstrated association between increased exposure to PFAS and dysregulation of blood lipds. Nevertheless, these studies did not investigate this relationship throughout an individual’s lifespan. One group that warrants special attention in this regard is women experiencing the menopausal transition. This period is characterized by hormonal changes, including reduced estrogen levels and increased androgens, which have the potential to contribute to the onset of metabolic disorders.
Furthermore, menopause is known to bring about alterations in the concentrations of various lipids present in the bloodstream, such as lipoproteins, apolipoproteins, low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), and triacylglycerol (TG).
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