Spatial Variations in Per-and Polyfluoroalkyl Substance Concentrations in Pooled Sera from Inland, Coastal, and Island Populations
By Julia J. Orr, Leisa-Maree Toms, Peter Hobson, Carl Kennedy, Daman Langguth, Nathaniel Kucharski, Adriana Santivanez Olazo, Jochen F. Mueller, and Sandra Nilsson
Environmental Research
November 28, 2024
DOI: 10.1016/j.envres.2024.120482
Per- and polyfluoroalkyl substances (PFAS) are a class of ubiquitously detected chemicals, some of which are highly persistent and bioaccumulative in humans. Within the general population, dietary ingestion is considered a primary pathway for PFAS exposure, and seafood consumption specifically has been associated with higher serum PFAS concentrations. Proximity of residence to the ocean may influence dietary habits, particularly seafood consumption, and exposure to geographically specific PFAS sources such as sea spray aerosols (SSA). The objective of this study was to evaluate potential spatial trends in serum PFAS concentrations between Australian coastal and island populations compared to those with inland residency. Human sera were obtained from deidentified surplus pathology samples and pooled with respect to geographical location, sex (male or female), and age group (males: ≥15-<45 years, ≥45 years; females: ≥15-<45 years, ≥45-<60 years, ≥60 years) stratification criteria. Serum samples were then analysed for PFAS using High Performance Liquid Chromatography-Mass Spectrometry (HP LC-MS). A total of 13 of the 45 targeted PFAS were quantifiable in at least one pooled sample, including the detection of perfluorooctane sulfonate (PFOS) replacement compounds 5:3 fluorotelomer carboxylic acid (5:3 FTCA) and potassium 9-chlorohexadecafluoro-3-oxanonane-1-sulfonate (9Cl-F53B). Significant spatial trends were observed in males aged ≥45 years, with serum concentrations of PFOS, perfluorobutanoic acid (PFBA), perfluorodecanoic acid (PFDA) and perfluoroheptane sulfonic acid (PFHpS) demonstrated to be 32-77% higher in pooled samples from island locations compared with inland. A similar trend was observed for PFHpS in coastal locations. Whilst deidentification of samples limited inferences about exposure pathways associated with the observed trends, this study indicated the feasibility of utilising pooled samples for assessing spatial variations in serum PFAS concentrations between geographically distinct subpopulations.
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