Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models
30 Apr 2024 | Environ Sci Technol
Six PFAS compounds were found to disrupt cell fate determination, cilia formation, and gene expression in human embryonic stem cell models, signaling potential adverse health effects on early embryonic development.
Associations between serum perfluoroalkyl and polyfluoroalkyl concentrations and diabetes mellitus in the Korean general population: Insights from the Korean National Environmental Health Survey 2018-2020
26 Apr 2024 | Int J Hyg Environ Health
PFAS exposure and prediabetes risk in the general Korean population was found to have a significant positive association between specific PFAS compounds, such as PFHxS and PFOS, and the risk of pre-diagnostic diabetes and prediabetes.
A Review of Sample Collection and Analytical Methods for Detecting Per- and Polyfluoroalkyl Substances in Indoor and Outdoor Air
26 Apr 2024 | Chemosphere
This review of two decades of research on PFAS in outdoor and indoor air highlights the persistent presence of various PFAS, including those such as fluorotelomer alcohols and perfluorinated carboxylic acids and thousands more estimated, indicating ongoing environmental contamination despite regulatory measures, underscoring the need for improved air sampling techniques to comprehensively assess PFAS atmospheric distribution.
Sub-acute exposure of male guppies (Poecilia reticulata) to environmentally relevant concentrations of PFOA and GenX induces significant changes in the testis transcriptome and reproductive traits
26 Apr 2024 | Environ Int
Exposure of male guppies to environmentally realistic levels of a legacy PFAS and its replacement compound (GenX) resulted in altered reproductive traits, including changes in sexual behavior and sperm motility, as well as gene expression related to immune regulation. These changes highlight the potential adverse effects of PFAS on behavior, fertility, and immunity in fish populations.
Characterization of Per- and Polyfluoroalkyl Substances (PFAS) and Other Constituents in MSW Landfill Leachate from Puerto Rico
25 Apr 2024 | Chemosphere
Puerto Rico was found to have significantly elevated levels of PFAS in landfill leachate, with 51 PFAS detected above quantitation limits, including previously unreported compounds, indicating a potential risk to island environments and emphasizing the need for informed solid waste management decisions to mitigate PFAS contamination, especially in light of extreme climate events and drinking water contamination.
Quantifying Disparities in Per- and Polyfluoroalkyl Substances (PFAS) Levels in Drinking Water from Overburdened Communities in New Jersey, 2019-2021
24 Apr 2024 | Environ Health Perspect
63% of New Jersey's community water systems (serving 84% of the population) tested from 2019 to 2021 had PFAS detections, with overburdened communities more likely to have detections and exposure surpassing state maximum contaminant levels, and a higher proportion of people of color living in affected areas compared to non-Hispanic white populations.
[Perspective] Per- and Polyfluoroalkyl Substances in Drinking Water-Disparities in Community Exposures Based on Race and Socioeconomic Status
24 Apr 2024 | Environ Health Perspect
Systematic testing and public engagement, especially in rural and private well-dependent communities, are essential to addressing PFAS exposure data gaps and fully assessing disparities in exposures and health risk.
Nationwide distribution of perfluoroalkyl ether carboxylic acids in Chinese diets: An emerging concern
22 Apr 2024 | Environment International
PFECAs, particularly HFPO-DA, were found in high concentrations in Chinese diet samples, with estimated daily intake levels nearing or exceeding safety benchmarks set by the US EPA, especially in cereals.
Zürich II Statement on Per- and Polyfluoroalkyl Substances (PFASs): Scientific and Regulatory Needs
22 Apr 2024 | ES&T
A review from PFAS scientists and regulators summarizes key progress in science and policy, ongoing issues to be addressed, and possible ways forward for reducing harm from PFAS.
PFAS in Nigeria: Identifying data gaps that hinder assessments of ecotoxicological and human health impacts
21 Apr 2024 | Heliyon
This review examines the impact of PFAS in Nigeria, highlighting their persistence and health risks, and recommends strengthening regulations and increasing collaborative research and education for improved management and healthier communities.
Relationship between crustacean consumption and serum perfluoroalkyl substances (PFAS): the Korean National Environmental Health Survey (KoNEHS) cycle 4
19 Apr 2024 | Ann Occup Environ Med
Frequent consumption of crustaceans is linked to higher concentrations of PFAS such as PFOS, PFNA, and PFDeA in the blood of the general Korean population.
Partitioning of PFAS to serum, tissues, eggs, and hatchlings of an Australian freshwater turtle
15 Apr 2024 | J. Hazard. Mater.
Higher levels of certain PFAS were discovered in male turtles compared to females, with PFOS being the most prevalent in the turtles' tissues, while PFHxA was predominant in the surrounding water. All of the long chain PFAS were transferred from yolk to hatchling, suggesting an intergenerational effect.
Associations of per-and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the US adult population
13 Apr 2024 | Environmental Health
Exposure to certain PFAS chemicals is associated with a reduced risk of rheumatoid arthritis, especially in females, according to a study analyzing data from over 10,000 adults.
In-Vitro Effects of Perfluorooctanoic Acid on Human Sperm Function: What Are the Clinical Consequences?
11 Apr 2024 | J. Clin. Med.
Exposure to PFOA in-vitro reduces sperm motility and damages sperm quality, suggesting a possible negative impact on male fertility.
Association of Combined Per-and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease
11 Apr 2024 | IJERPH
Exposure to PFAS and metals like cadmium and mercury is associated with chronic kidney disease, with cadmium showing a consistent link and mercury having a significant but complex relationship, emphasizing the need for targeted public health interventions.