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• Prenatal exposure to per- and polyfluoroalkyl substances and childhood autism-related outcomes

  Science

  12 Jan 2023 | Epidemiology

  Mothers’ prenatal blood concentrations of PFNA may be associated with modest increases in their child’s autism-related traits.

• Per- and polyfluoroalkyl substances (PFAS) in breast milk and infant formula: A global issue

  Science

  3 Jan 2023 | Environ. Res.

  Breast milk concentrations of PFOA and PFOS often exceed children’s drinking water screening values, and limited information on infant formula means that families cannot generally know whether their infant’s exposures exceed safe levels.

• Human serum poly- and perfluoroalkyl substance concentrations and their associations with gestational diabetes mellitus

  Science

  6 Dec 2022 | Environ Pollut

  Higher serum PFAS concentrations were associated with gestational diabetes incidence in pregnant women, especially for PFOA, PFNA, PFHxS, and 6:2 Cl-PFESA.

• Bayesian Estimation of Human Population Toxicokinetics of PFOA, PFOS, PFHxS, and PFNA from Studies of Contaminated Drinking Water

  Science

  1 Dec 2022 | Environ Health Perspect

  A harmonized methodology was developed to determine the half-life and volume of distribution for PFOA, PFOS, PFNA, and PFHxS.

• Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study

  Science

  19 Nov 2022 | Environ Health

  PFAS exposures in childhood are negatively associated with overall bone mass density, with the strongest association seen for PFNA amongst 5-year-olds.

• The effects of perfluoroalkyl and polyfluoroalkyl substances on female fertility: A systematic review and meta-analysis

  Science

  2 Nov 2022 | Environ Res

  Increased levels of PFAS exposure are associated with reduced female fertility, which should be taken into account for risk assessments of manufacturing products containing PFAS.

• Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada

  Science

  14 Oct 2022 | Chemosphere

  Long-chain PFAAs levels were 4–7 fold higher in Nunavik Inuit adults compared to the Canadian population and were associated with hunting activity, omega-3 fatty acids, and drinking water from environmental sources.

• Emerging contaminants migration from pipes used in drinking water distribution systems: a review of the scientific literature

  Science

  20 Sep 2022 | Environ Sci Pollut Res Int

  PFOA, PFNA, PFDA, PFOS, and PFHxS were detected at levels indicating a potential non-carcinogenic health risk to consumers.

• Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study

  Science

  7 Sep 2022 | Environ Health Perspect

  PFNA and PFOS exposure through drinking water was associated with higher levels of total cholesterol, especially in older adults.

• Association between fish oil supplements use and serum per- and polyfluoroalkyl substances (PFAS): Results from the National Health and Nutrition Examination Survey

  Science

  29 Aug 2022 | Environ Res

  Fish oil supplement consumers did not have increased serum PFAS levels, specifically, but some inverse associations observed between the supplement use and PFOS levels in older adults and females need further study.

• Associations of single and multiple perfluoroalkyl substances exposure with folate among adolescents in NHANES 2007-2010

  Science

  15 Aug 2022 | Chemosphere

  Exposure to PFOS, PFOA, PFNA, and PFDA was associated with lower blood folate concentrations.

• Outside the Safe Operating Space of a New Planetary Boundary for Per-and Polyfluoroalkyl Substances (PFAS)

  Science

  2 Aug 2022 | ES&T

  PFAS have been detected at unsafe levels in rain globally, leading to the conclusions that the spread of PFOS, PFOA, PFHxS, and PFNA in the atmosphere has exceeded levels of concern for chemical pollution and that PFAS uses and emissions should be rapidly restricted.

• Increasing Accumulation of Perfluorocarboxylate Contaminants Revealed in an Antarctic Firn Core (1958–2017)

  Science

  26 Jul 2022 | ES&T

  PFCA and PFBA accumulation in snow increased, and although chemical fluxes of PFOA and PFNA peaked in 2009–2013, there is little evidence of a decline in PFAAs despite supposed recent global curtailments in their production.

• Associations of prenatal exposure to perfluoroalkyl substances with preterm birth: A family-based birth cohort study

  Science

  7 Jul 2022 | Environ Res

  Higher family-level PFNA and PFDA exposure were associated with greater preterm birth risk, but the results on an individual level were contradictory.

• Exposure to perfluoroalkyl substances and neurodevelopment in 2-year-old children: A prospective cohort study

  Science

  7 Jul 2022 | Environ Int

  PFAS exposure during early pregnancy was significantly associated with an adverse neurodevelopmental status at two years of age, raising a serious public health concern.