Showing 1-15 of 312
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Residential proximity to transport facilities as urban determinants of individual-level per- and poly-fluoroalkyl substance (PFAS) exposures: Analysis of two longitudinal cohorts in Singapore
Science
9 Jan 2026 | Environ Health
A longitudinal study of pregnant women in Singapore reports that residential proximity to large transport facilities, especially bus depots, is associated with higher blood levels of specific PFAS, notably PFBS, PFBA, and PFNA, highlighting a potentially important but largely unregulated urban exposure source linked to the widespread use of PFAS in automotive lubricants, hydraulic fluids, coatings, and other vehicle components.
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An integrated in vitro and in silico testing strategy applied to PFAS inhibition of antibody production to define a tolerable daily intake
Science
3 Jan 2026 | Toxicol Lett
PFOS, PFOA, PFNA, and PFHxS, may inhibit antibody production, with modeled human-equivalent effect doses that are similar to or lower than existing European Food Safety Authority health-based guidance values.
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Serum perfluoroalkyl and polyfluoroalkyl substances and the risk of cardiometabolic diseases: Unraveling the mediating role of inflammatory markers
Science
24 Dec 2025 | Eco Environ Health
Combined exposure to several PFAS was associated with increased risk of cardiometabolic conditions, particularly abnormal blood lipids and high blood pressure, with specific PFAS such as PFHxS, PFNA, and PFTrDA emerging as potential key contributors.
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Mediating role of proteomics in the association between per-and polyfluoroalkyl substance exposure and blood pressure in youth
Science
15 Dec 2025 | Environ Pollut.
PFOA, PFNA, PFOS, PFHxS, and PFHpS, exposure may be associated with higher blood pressure in youth through protein changes (particularly galectin-3) involving inflammatory and scarred tissue.
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Assessing the impact of perfluoroalkyl substances on liver health: A comprehensive study using multi-donor human liver spheroids
Science
8 Dec 2025 | Environ. Int.
PFHxS, PFOA, PFOS, and PFNA may interfere with liver function in different ways depending on the specific chemical and the sex of the donor cells, potentially contributing to fat buildup in the liver, weakened immune activity, and molecular changes linked to cancer development.
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Concentrations of per- and polyfluoroalkyl substances in Canadian sea otters (Enhydra lutris) are higher near urban centers
Science
4 Nov 2025 | Environ Toxicol Chem
PFAS were detected in all sampled British Columbia sea otters, with liver concentrations over 25 times higher than in muscle tissue and dominated by PFNA, PFOSA, and PFOS.
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Childhood exposure to per-and polyfluoroalkyl substances during eating activities: Occurrence, exposure, and developmental risk
Science
3 Nov 2025 | J. Environ. Chem. Ecotoxicol.
Children’s feeding bibs and tablecloths were found to contain multiple PFAS, including PFOA, PFNA, and PFOS. Modeled hand-to-mouth exposure during meals was estimated to approach or exceed safety thresholds for infants that potentially disrupt hormone and developmental pathways.
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Changes in the levels and predictors of per-and poly-fluoroalkyl substances in maternal plasma, relative to timelines of EPA PFOA Stewardship
Science
18 Oct 2025 | Environ. Int.
PFOS, PFOA, PFHxS, PFHpS, and Me-PFOSA-AcOH declined over time after EPA’s PFOA Stewardship Program, but other PFAS such as PFNA, PFUnA, PFDeA, PFDoA, and GenX increased especially among non-White mothers, and higher levels were linked to eating fish/shellfish and vegetables, working, and having carpet or pets during pregnancy, showing that policies reduced some PFAS but exposure sources and inequities remain.
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An unwanted hitchhiker: Assessment of per-and polyfluoroalkyl substances (PFAS) in vehicle cabin air conditioner and engine filters
Science
10 Oct 2025 | Analytical Methods
Car cabin air filters were dominated by diPAPs and long-chain PFCAs (like PFOA, PFNA, and PFDA), showing far higher PFAS levels than engine filters, which mainly contained fluorotelomer sulfonic acids and some PFCAs, indicating that vehicle interiors are a significant source of PFAS exposure.
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The moderating role of vitamin E in the association between PFAS exposures and diabetes risk: Evidence from the NHANES 2017-2018
Science
22 Sep 2025 | Metabolism Open
Analysis of U.S. NHANES 2017–2018 data showed that higher PFAS concentrations, especially PFOS and PFNA, were linked to increased diabetes risk, but vitamin E significantly moderated these effects by reducing PFAS-related elevations in blood glucose, suggesting antioxidant protection is particularly important for older adults and men.
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Associations between per- and polyfluoroalkyl substances and type 2 diabetes: The modifying effects of lifestyle and genetic risk
Science
23 Aug 2025 | J Hazard Mater
Certain PFAS chemicals (like PFOA, PFNA, PFBA, and PFHpA) are linked to a higher risk of type 2 diabetes and these effects are made stronger by lifestyle choices and high genetic risk.
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Multi-site study of communities with PFAS-contaminated drinking water: Methods, demographics, and PFAS serum concentrations
Science
11 Aug 2025 | Environ. Int.
In eight PFAS-affected U.S. communities, blood tests of 5,826 adults and 710 children from 2019 to 2023 found higher PFHxS and PFOA in adults and higher PFHxS only in children.
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Serum Levels of Per- and Polyfluoroalkyl Substances in Adults Aged 18 and Older in Relation to the Length of Residency in United States
Science
11 Aug 2025 | J Immigr Minor Health
Immigrants to the U.S. tend to have lower levels of PFAS such as PFOA, PFOS, PFHxS, PFNA, and PFDeA upon arrival, but their levels increase over time, often matching those of U.S.-born people within 5 to 15 years, depending on race, ethnicity, and differences in past and ongoing environmental exposures.
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Association of serum per-and polyfluoroalkyl substances exposure with leukocyte telomere length in Chinese middle-aged and older adults: Role of genetic susceptibility and healthy diet
Science
16 Jul 2025 | Environ Sci Technol
In nearly 1,500 middle-aged and older Chinese adults, higher blood levels of the PFDA and PFUDA were linked to noticeably shorter telomeres, with the greatest shrinkage in people who also carried aging-related genes and ate a low-quality diet, suggesting these chemicals may speed biological aging.
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Levels of serum per- and polyfluoroalkyl substances and association with dyslipidemia in the Korean population
Science
7 Jul 2025 | Ecotoxicol Environ Saf
A large national study of nearly 3,000 Korean adults found widespread PFAS exposure and showed that higher serum concentrations of several compounds, especially PFOA, PFHxS, PFNA and PFDeA, were consistently associated with elevated low-density lipoprotein cholesterol and total cholesterol, implying potential cardiovascular risk and reinforcing the need for stricter regulation.