Showing 16-30 of 321
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Association of co-exposure to organophosphate esters and per- and polyfluoroalkyl substances and mixture with cardiovascular-kidney-liver-metabolic biomarkers among Chinese adults
Science
4 Jun 2024 | Ecotoxicol Environ Saf
Exposure to common environmental contaminants like organophosphate esters and PFAS, especially PFHxS and PFNA, is associated with disruptions in liver function and cholesterol levels, suggesting potential risks for chronic diseases due to their widespread presence in the human body.
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Investigation of the Link between Per- and Polyfluoroalkyl Substances and Stress Biomarkers in Bottlenose Dolphins
Science
14 May 2024 | Environ Sci Technol
Exposure to various PFAS chemicals in bottlenose dolphins from South Carolina and Florida correlates with changes in stress-related cortisol levels, suggesting PFAS may impact their stress response and highlighting the need for further long-term research.
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Per- and polyfluoroalkyl substances (PFAS) and fetal growth: A nation-wide register-based study on PFAS in drinking water
Science
8 May 2024 | Environ Int
A nationwide study in Sweden found no clear link between maternal exposure to certain PFAS during pregnancy and newborn birthweight or risk of being small-for-gestational-age, but did find a slight increase in the risk of being large-for-gestational-age, particularly associated with PFOS.
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Associations between serum perfluoroalkyl and polyfluoroalkyl concentrations and diabetes mellitus in the Korean general population: Insights from the Korean National Environmental Health Survey 2018-2020
Science
26 Apr 2024 | Int J Hyg Environ Health
PFAS exposure and prediabetes risk in the general Korean population was found to have a significant positive association between specific PFAS compounds, such as PFHxS and PFOS, and the risk of pre-diagnostic diabetes and prediabetes.
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Associations of per-and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the US adult population
Science
13 Apr 2024 | Environmental Health
Exposure to certain PFAS chemicals is associated with a reduced risk of rheumatoid arthritis, especially in females, according to a study analyzing data from over 10,000 adults.
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Prenatal exposure to mixtures of per- and polyfluoroalkyl substances and organochlorines affects cognition in adolescence independent of postnatal exposure
Science
5 Mar 2024 | Int J Hyg Environ Health
This study investigated the cognitive effects of prenatal exposure to PFAS and organochlorines, finding that higher prenatal exposure to these chemicals, particularly PFHxS and PFNA, is associated with improved sustained and selective attention during adolescence, regardless of exposure levels at adolescence. However, the authors suggest the results should be interpreted with caution due to limited understanding of biological pathways and prior studies showing neurotoxic effects from PFAS.
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Integrated Analysis of Per-and Polyfluoroalkyl Substance Exposure and Metabolic Profiling of Elderly Residents Living near Industrial Plants
Science
26 Feb 2024 | Environ. Sci. Technol.
Significant associations between PFAS exposure levels and metabolic profiles were identified among those residing near industrial plants, particularly within lipid metabolism pathways, shedding light on potential adverse health effects and emphasizing the importance of understanding and mitigating these risks.
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Associations of per- and polyfluoroalkyl substances with maternal metabolic and inflammatory biomarkers in early-to-mid-pregnancy
Science
10 Feb 2024 | Environ Res
Exposure to PFAS during early-to-mid pregnancy was associated with decreased insulin levels, increased HDL cholesterol, and alterations in inflammatory markers, suggesting potential metabolic and inflammatory disruptions that may impact maternal and fetal health.
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Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: A multicohort study
Science
27 Jan 2024 | Environ Int
Dietary factors, such as tea & pork intake and eating food not prepared at home, were associated with increases in blood levels of PFAS in young Hispanic adults, underscoring the significance of diet in PFAS exposure and the need for monitoring food and beverage contamination.
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Association of prenatal exposure to perfluorinated and polyfluoroalkyl substances with childhood neurodevelopment: A systematic review and meta-analysis
Science
10 Jan 2024 | Ecotoxicol Environ Saf
A meta-analysis on prenatal exposure to PFAS suggests a sex-specific relationship, revealing that PFOS, PFOA, and PFHxS are associated with decreased performance IQ in boys but PFOS was linked to increased performance IQ in girls, while PFAS are linked to executive function impairments in children without a significant association with behavioral difficulties.
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Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake
Science
10 Jan 2024 | Toxics
This study exposed mice to a mixture of PFAS at levels equivalent to estimated daily human intake, revealing that even low concentrations of PFAS caused liver tissue changes and altered gene expression related to metabolism and cancer, emphasizing the need for thorough toxicity assessments of these persistent environmental contaminants.
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Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
Science
30 Dec 2023 | Sci Total Environ
Exposure to PFOS may disrupt early skin development by altering cell morphology, gene expression, and crucial signaling pathways, suggesting a potential link between PFAS exposure and congenital skin diseases during embryonic development.
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Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs
Science
28 Dec 2023 | Environ Sci Technol
PFAS levels in the liver correlated well with other organs, supporting the use of blood concentrations as a measure of PFAS exposure and suggesting the liver as the primary organ of PFAS retention, with minor variations observed in other organs.
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Per-and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
Science
27 Dec 2023 | CGH
A connection was found between elevated PFAS levels and increased odds of Crohn’s disease and ulcerative colitis for up to 10 years prior to diagnosis, with both legacy and emerging PFAS chemicals implicated.
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Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study
Science
13 Dec 2023 | Environ Sci Technol
Prenatal exposure to a mixture of PFAS in mothers is linked to alterations in infant metabolic pathways, which can result in birthweight or vaccine response abnormalities.