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• Determination of Perflourooctanoic Acid Toxicity in a Human Hepatocarcinoma Cell Line

  Science

  14 Sep 2021 | J Health Pollut.

  PFOA is potentially hepatotoxic by triggering programmed cell death.

• Evaluation of the acute toxicity and neurodevelopmental inhibition of perfluorohexanoic acid (PFHxA) in zebrafish embryos

  Science

  14 Sep 2021 | Ecotoxicol Environ Saf

  High levels of PFHxA exposure was associated with permanent neurological damage in a human model organism.

• Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts.

  Science

  14 Sep 2021 | Environ Int

  Prenatal, rather than postnatal, PFAS exposure might contribute to increased obesity in children.

• The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure

  Science

  8 Sep 2021 | Toxicology

  PFAS mixtures were found to have increased detrimental effects, especially when transferred from mother to offspring.

• Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth

  Science

  8 Sep 2021 | Environ Health Perspect

  Youth exposure to PFHxS was associated with abnormal metabolism in females, especially after puberty.

• Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain

  Science

  8 Sep 2021 | Environ Res

  PFAS, including short chains, were found inside the brain circumnavigating the blood-brain barrier.

• Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury

  Science

  8 Sep 2021 | Environ Int

  Exposure of mice to a mixture of PFAS results in abnormal modulation of cholesterol levels leading to increased liver weight and inflammation.

• Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco

  Science

  7 Sep 2021 | Environ Health

  Positive associations between PFAS and telomere length in women workers, with larger effects seen among firefighters as compared to office workers.

• Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha

  Science

  4 Sep 2021 | Environ Pollut

  Exposure to HFPO-DA induced developmental cardio-toxicity and hepatotoxicity in hatchling chickens similar to PFOA

• The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid

  Science

  2 Sep 2021 | Chemosphere

  PFBS exposures were found to alter egg and embryo development, when exposure occurs preconception.

• Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study

  Science

  31 Aug 2021 | Int J Environ Res Public Health

  PFOA and PFOS were positively associated with developing cardiovascular diseases and their risk factors.

• Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice

  Science

  31 Aug 2021 | Environ Pollut

  Potential gut toxicity of HFPO-DA and is perceived as a major problem of health risk that affects inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals.

• Early pregnancy loss: Do Per- and polyfluoroalkyl substances matter?

  Science

  31 Aug 2021 | Environ Int

  Overall, we suggest that most PFAS were not associated with early pregnancy loss at the current exposure levels.

• Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy: The HOME Study

  Science

  25 Aug 2021 | Environ Int

  HFPO-DA was found to potentially be a major problem of health risk that affects inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals.

• Perfluorooctane sulfonate (PFOS) disturbs fatty acid metabolism in Caenorhabditis elegans: Evidence from chemical analysis and molecular mechanism exploration

  Science

  17 Aug 2021 | Chemosphere

  PFOS was found to inhibit energy synthesis during fatty acid metabolism in a model species.