Showing 691-705 of 4346
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Binding of Per- and Polyfluoroalkyl Substances (PFAS) to Serum Proteins: Implications for Toxicokinetics in Humans
Science
3 Jan 2024 | Environ Sci Technol
PFAS binding to major blood serum proteins is thought to affect toxicity, transport, and half-lives in the body. This study found shorter-chain PFAS showing a stronger binding to human serum albumin and longer-chain PFAS displaying a greater affinity for globulins, emphasizing the significance of understanding these interactions for more precise assessments of PFAS impact on human health in epidemiological studies.
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Assessing potential human health and ecological implications of PFAS from leave-in dental products
Science
3 Jan 2024 | Toxicol Ind Health
PFBA and PFOS were found in low levels in night guards with no detection in whitening trays, suggesting these dental products are unlikely to pose health concerns or contribute significantly to environmental PFAS exposure compared to exposure from food and water.
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Overview of PFAS Regulations in the United States and What Japanese Companies and Their U.S. Subsidiaries Need to Know
Policy
2 Jan 2024
This article provides an overview of PFAS regulation in the United States, emphasizing its relevance to various Japanese businesses, including those in specialty chemicals, manufacturing, oil and gas, and trading, due to the widespread use of PFAS in commercial products, potential liability risks, and recent multi-billion dollar settlements in PFAS contamination lawsuits.
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Investigating the progression of preeclampsia through a comprehensive analysis of genes associated with per- and polyfluoroalkyl substances
Science
2 Jan 2024 | Toxicol Mech Methods
Using advanced analysis of genetic data, researchers identified a potential link between PFAS and the risk of preeclampsia, suggesting that these environmental factors may play a role in the development of the disease, and highlighted six genes with diagnostic potential for preeclampsia.
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‘I’ve been drinking poison for 30 years’: West Plains residents reckon with slow-moving PFAS cleanup
News
31 Dec 2023 | The Columbian
“My emotions have been on a roller coaster for the last couple of months. Anger. Disappointment. Verging on heartbreak,” Danner said in a mid-December interview. “I’ve been drinking poison for 30 years and there’s nothing going to be done about it anytime soon.”
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Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
Science
30 Dec 2023 | Sci Total Environ
Exposure to PFOS may disrupt early skin development by altering cell morphology, gene expression, and crucial signaling pathways, suggesting a potential link between PFAS exposure and congenital skin diseases during embryonic development.
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‘Forever chemicals’ found in freshwater fish, yet most states don’t warn residents
News
29 Dec 2023 | Brudge Michigan
With no federal guidance, what is considered safe to eat varies significantly among states, most of which provide no regulation.
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‘Forever chemicals’ were everywhere in 2023. Expect more litigation in 2024
News
28 Dec 2023 | Reuters
Lawsuits accusing major chemical companies of polluting U.S. drinking water with toxic PFAS chemicals led to over $11 billion in settlements in 2023, with experts predicting that new federal regulations and a growing awareness of the breadth of PFAS contamination in the U.S. will spur more litigation and settlements in the year ahead.
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Prenatal per- and polyfluoroalkyl substances exposure and gut microbiota of infants: A prospective cohort study
Science
28 Dec 2023 | Ecotoxicol Environ Saf
In a study of 69 mother-child pairs, PFAS was associated with changes in the gut microbiota of infants, potentially linking these alterations to known health impacts later in life.
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Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs
Science
28 Dec 2023 | Environ Sci Technol
PFAS levels in the liver correlated well with other organs, supporting the use of blood concentrations as a measure of PFAS exposure and suggesting the liver as the primary organ of PFAS retention, with minor variations observed in other organs.
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Per-and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
Science
27 Dec 2023 | CGH
A connection was found between elevated PFAS levels and increased odds of Crohn’s disease and ulcerative colitis for up to 10 years prior to diagnosis, with both legacy and emerging PFAS chemicals implicated.
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Firefighter's Cancer Leads Wife to Discovery of Toxic Gear Killing Heroes Across U.S.: ‘It’s Infuriating’
News
27 Dec 2023 | People
Since 2002 cancer has been responsible for the deaths of almost two out of every three firefighters, according to the International Association of Fire Fighters.
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Inside the Pentagon's Painfully Slow Effort to Clean Up Decades of PFAS Contamination
News
27 Dec 2023 | Military.com
Thirteen years later, the community is still waiting on whatever it will take to clean its water. As a result of dogged activism and pressure from government officials, the Air Force has finally taken initial steps simply to contain the chemicals.
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GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways
Science
27 Dec 2023 | Chem Res Toxicol
GenX, a substitute for PFOA, was found to cause liver damage and disrupt lipid metabolism in mice even at low environmental concentrations when exposed to drinking water.
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Prenatal Exposure to Poly- and Perfluoroalkyl Substances (2009-2014) and Vaccine Antibody Titers of Measles, Mumps, Rubella, and Varicella in Children Four to Eight Years Old from the Healthy Start Cohort
Science
26 Dec 2023 | Environ Health Perspect
Prenatal exposure to PFAS is linked to lower antibody levels in fully immunized children, particularly for measles and mumps, suggesting potential immunotoxic effects.