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As EPA tries to loosen PFAS rules, NC regulators inch toward statewide protections
Policy
9 Jan 2026
Members of the Environmental Management Commission expressed the need for some urgency in moving forward with the development of statewide rules on Thursday. The group took up two sets of “monitoring and minimization rules”: one for three types of PFAS – PFOS, PFOA and GenX – and another for 1,4-Dioxane.
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Bioaccumulation of PFOS Isomers in Transporter Proteins
Science
8 Jan 2026 | Chem Res Toxicol
Structural differences among PFOS isomers are associated with differing interactions with fatty acid transporter proteins, with some branched isomers potentially exhibiting comparable or greater bioaccumulation potential than linear PFOS based on combined in vitro uptake and molecular modeling results.
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High PFAS levels in Wisconsin eaglets may reduce their ability to fend off illness
News
7 Jan 2026 | Wisconsin Public Radio
Samples also showed PFOS, one of the most widely studied PFAS chemicals, made up as much as 90 percent of the total PFAS. Dehnert noted fish consumption guidelines advise people not to eat fish that contain PFOS levels above 40 parts per billion.
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An integrated in vitro and in silico testing strategy applied to PFAS inhibition of antibody production to define a tolerable daily intake
Science
3 Jan 2026 | Toxicol Lett
PFOS, PFOA, PFNA, and PFHxS, may inhibit antibody production, with modeled human-equivalent effect doses that are similar to or lower than existing European Food Safety Authority health-based guidance values.
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Fate, bioaccumulation, and toxic responses of PFOA, PFOS, and GenX in the paddy soil-rice system across the full growth cycle
Science
1 Jan 2026 | J Hazard Mater
Analysis of a full growth cycle study in paddy soil suggests that PFOA, PFOS, and the replacement PFAS GenX may disrupt rice growth and induce oxidative stress. GenX is showing greater upward movement into edible tissues, highlighting potential food-chain relevance and informing proposed soil safety thresholds for rice cultivation.
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Formation of perfluorocarboxylic acids (PFCAs) from the incomplete thermal decomposition of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA
Science
16 Dec 2025 | ACS ES&T Air
PFOS and PFOA thermal treatment may consistently produce multiple perfluorocarboxylic acids and volatile fluorinated byproducts at suboptimal temperatures despite near-complete parent destruction, highlighting potential emissions concerns and uncertainties about the specific formation pathways.
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Mediating role of proteomics in the association between per-and polyfluoroalkyl substance exposure and blood pressure in youth
Science
15 Dec 2025 | Environ Pollut.
PFOA, PFNA, PFOS, PFHxS, and PFHpS, exposure may be associated with higher blood pressure in youth through protein changes (particularly galectin-3) involving inflammatory and scarred tissue.
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Co-exposure to PFAS and hydroxylated PCBs is associated with increased odds of multiple sclerosis
Science
11 Dec 2025 | Environ Int
Swedish adults with background exposure who had higher serum levels of PFOS and PCB breakdown products may face increased odds of developing multiple sclerosis, with the strongest associations observed at higher exposure ranges after accounting for lifestyle and genetic differences.
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Investigating anaerobic digestion microbiome resilience to high PFOA and PFOS mixtures during cometabolism
Science
8 Dec 2025 | Bioresour. Technol.
High levels of PFOA and PFOS may interfere with how microbes create biogas during anaerobic digestion, which is important for waste-treatment policy because it suggests these chemicals can disrupt sludge processing while showing no clear signs of degradation.
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Assessing the impact of perfluoroalkyl substances on liver health: A comprehensive study using multi-donor human liver spheroids
Science
8 Dec 2025 | Environ. Int.
PFHxS, PFOA, PFOS, and PFNA may interfere with liver function in different ways depending on the specific chemical and the sex of the donor cells, potentially contributing to fat buildup in the liver, weakened immune activity, and molecular changes linked to cancer development.
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Development and validation of an LC-MS/MS method for simultaneous determination of 39 PFAS in soil samples: applications to playgrounds in Attica, Greece
Science
4 Dec 2025 | Anal Bioanal Chem
An optimized research method was found to be a useful tool for environmental and public-health decision making by reliably detecting 39 PFAS in playground soils, and the results suggest that some PFAS levels may potentially exceed a precautionary child-health screening value of about 100 ng per kg of body weight per day.
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Assessing PFAS exposure in Rocky Mountain elk (Cervus canadensis nelsoni) populations adjacent to the former Rocky Flats nuclear site: A preliminary analysis.
Science
1 Dec 2025 | PLoS One
Preliminary analysis finds that PFOS was consistently detected in elk livers at both Rocky Flats and control sites while PFOA was not detected, suggesting that PFOS may accumulate in elk regardless of proximity to known contamination sources and highlighting potential wildlife exposure pathways and implications for game consumption.
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Arsenic, Cadmium, Lead, Mercury, and PFAS Exposure During Pregnancy or Lactation and Respective Concentrations in Human Milk: Systematic Review
Science
26 Nov 2025 | Environ Res
Evidence from 46 studies suggests that higher maternal exposure to lead, mercury, PFOA, and PFOS may be linked with higher concentrations of the same contaminants in human milk, potentially exposing infants during critical development windows.
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Bone marrow accumulation of perfluoroalkyl substances (PFASs) predicts post-transplant relapse in acute myeloid leukemia patients and associated with T-cell dysregulation
Science
25 Nov 2025 | Ecotoxicol Environ Saf
Higher early post-transplant levels of PFOA, PFOS, 9Cl-PF3ONS, and PFUnDA in the bone marrow of leukemia patients were linked to patterns of T-cell disruption associated with relapse, pointing to a potential environmental influence on immune recovery after a transplant.
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The unintentional role of chemical regulation in regrettable substitution: The case of PFAS
Science
25 Nov 2025 | ES&P
The authors argue that regulatory systems like TSCA and REACH may unintentionally drive regrettable PFAS substitutions by allowing insufficiently assessed alternatives onto the market, highlighting the policy significance of shifting toward earlier hazard evaluation, coordinated global oversight, and mechanisms to prevent substitution with equally persistent or hazardous chemicals.