Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.

By Eleni Papadopoulou, Line Småstuen Haug, Amrit Kaur Sakhi, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Sílvia Fernández-Barrés, Regina Grazuleviciene, Helle Katrine Knutsen, Lea Maitre, Helle Margrete Meltzer, Rosemary R C McEachan, Theano Roumeliotaki, Remy Slama, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen, and Leda Chatzi
Environ. Health Perspect.
October 23, 2019
DOI: 10.1289/EHP5324

Background

Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status.

Objectives

Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth cohorts ( mothers and 1,288 children).

Methods

We assessed the consumption of seven food groups and the blood levels of organochlorine pesticides, polybrominated diphenyl ethers, polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFAS), and heavy metals and urinary levels of phthalate metabolites, phenolic compounds, and organophosphate pesticide (OP) metabolites. Organic food consumption during childhood was also studied. We applied multivariable linear regressions and targeted maximum likelihood based estimation (TMLE).

Results

Maternal high () versus low () fish consumption was associated with 15% higher PCBs [geometric mean (GM) ; 95% confidence interval (CI): 1.02, 1.29], 42% higher perfluoroundecanoate (PFUnDA) (; 95% CI: 1.20, 1.68), 89% higher mercury (Hg) (; 95% CI: 1.47, 2.41) and a 487% increase in arsenic (As) (; 95% CI: 2.57, 9.23) levels. In children, high () versus low () fish consumption was associated with 23% higher perfluorononanoate (PFNA) (; 95% CI: 1.08, 1.40), 36% higher PFUnDA (; 95% CI: 1.12, 1.64), 37% higher perfluorooctane sulfonate (PFOS) (; 95% CI: 1.22, 1.54), and higher Hg and As [ (95% CI: 1.91, 4.31) and (95% CI: 2.23, 3.21)] concentrations. Using TMLE analysis, we estimated that fish consumption within the recommended 2-3 times/week resulted in lower PFAS, Hg, and As compared with higher consumption. Fruit consumption was positively associated with OP metabolites. Organic food consumption was negatively associated with OP metabolites.

Discussion

Fish consumption is related to higher PFAS, Hg, and As exposures. In addition, fruit consumption is a source of exposure to OPs. https://doi.org/10.1289/EHP5324.

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