Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6: 2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
By Penelope A. Rice, Shruti V. Kabadi, Daniel R. Doerge, Michelle M. Vanlandingham, Mona I. Churchwell, Volodymyr P. Tryndyak, Jeffrey W. Fisher, Jason Aungst, and Frederick A. Beland
FCT
January 16, 2024
DOI: 10.1016/j.fct.2023.114333
The 6:2 fluorotelomer alcohol (6:2 FTOH) is a common impurity in per- and polyfluoroalkyl substances (PFASs) used in many applications. Our previous toxicokinetic (TK) evaluation of 6:2 FTOH calculated times to steady state (tss) of one of its metabolites, 5:3 fluorotelomer carboxylic acid (5:3A), in the plasma and tissues of up to a year after oral exposure to rats. Our current work further elucidated the TK of 5:3A and other metabolites of 6:2 FTOH in pregnant and nonpregnant rats after repeated oral exposure and examined the role of renal transporters in the biopersistence of 5:3A. The tss values for 5:3A in serum and tissues of adult nonpregnant animals ranged from 150 days to over a year. 4:3 fluorotelomer carboxylic acid (4:3A) was an additional potentially-biopersistent metabolite. 5:3A was the major metabolite of 6:2 FTOH in serum of pregnant dams and fetuses at each time interval. 5:3A was not a substrate for renal transporters in a human kidney cell line in vitro, indicating that renal reuptake of 5:3A is unlikely contribute to its biopersistence. Further research is needed to identify the underlying processes and evaluate the impact of these 6:2 FTOH metabolites on human health.
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