Subchronic Effects of Perfluorooctane Sulphonate on the Testicular Morphology and Spermatogenesis in Mice

By De-Yong Zhang, Xiao-Lu Xu, Qin Ruan, Xiu-Ying Shen, Yin Lu
Pak. Jour. of Zoo.
October 31, 2019
DOI: 10.17582/journal.pjz/2019.51.6.2217.2223

To determine the subchronic male reproductive toxicity of PFOS, male mice were administrated with a serial dosage of PFOS for 90 days for testicular observation and spermatogenesis evaluation. PFOS = 11 mg/kg (accumulative dosage) resulted in visible histopathological changing in testis, including disorder and vacuolization of spermatogenic cells. Changed testicular organ coefficient (for dosage = 55 mg/kg), decreased sperm concentration (for 110 mg/kg dosage), decreased motility (for 110 mg/kg dosage) and increased sperm malformation (for all of the treated groups) were also confirmed (p<0.05). Sperm malformation showed high sensitivity to PFOS exposure. A sperm malformation percentage, varying from 11.00% to 51.20%, was confirmed for the treated groups. As to various sperm malformation types, curved body type constituted the most proportion. The treated groups showed a curved body malformation percentage varied from 8.00% to 43.5%, due to different PFOS dosage. The observations indicate that subchronic exposure of PFOS can interfere with spermatogenesis process and affect sperm quality in mammals.

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