The effects of Cl-PFESAs exposure on blood lipids - A community-based large population study in Guangzhou

By Xin Mi, Lu-Yin Wu, Jiao-Jiao Liu, Qiu-Ling Fang, Zhengmin Min Qian, Chu Chu, Qing-Qing Li, Fan Su, Yun-Ting Zhang, Peien Zhou, Xiao-Wen Zeng, Hong-Yao Yu, Pengxin Dong, Yang Zhou, Yanqiu Ou, Shimin Xiong, Xubo Shen, Wenru Feng, Yuanzhong Zhou, and Guang-Hui Dong
Sci Total Environ
October 5, 2021
DOI: 10.1016/j.scitotenv.2021.150634

Numerous epidemiological studies have investigated the lipid interference effects of legacy PFASs, however, no studies on PFAS alternatives and blood lipids have been published. In this study, we explored the association between Cl-PFESAs, a typical PFASs alternative in China, and blood lipid profiles in 1336 Guangzhou community residents using linear and non-linear regression models. The results showed a deleterious effect of Cl-PFESAs and blood lipids: adjusted estimates (β) for TC, TG, LDL-C and HDL-C per natural log unit increase of 6:2 Cl-PFESA were 0.029 (95% CI: 0.020, 0.038), 0.075 (95% CI: 0.049, 0.101), 0.035 (95% CI: 0.021, 0.049) and -0.071 (95% CI: -0.084, -0.058), respectively. The association between Cl-PFESAs and dyslipidemia was also positively significant (P < 0.05). Furthermore, a non-linear relationship was observed in Cl-PFESAs and serum lipid levels using a restricted cubic splines (RCS) model. In summary, our research suggested a negative impact of Cl-PFESAs on blood lipid patterns and a possible non-linear association.

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