Tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol and its metabolites in pigs after oral exposure
By Shuyu Xie, Yonghui Cui, Yujuan Yang, Kuiyu Meng, Yuanhu Pan, Zhenli Liu, and Dongmei Chen
Chemosphere
February 25, 2020
DOI: 10.1016/j.chemosphere.2020.126016
The tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol (8:2 FTOH) were evaluated in pigs after oral exposure of a dose of 5 mg/kg.b.w.d. for 7 d. The bioaccumulation of 8:2 FTOH and its metabolites showed significant differences among the various tissues. The parent compound was quickly depleted, and the main metabolites perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA), and 3-perfluoroheptyl propanoic acid (7:3 FTCA) were detected in all tissues examined. The relative elimination half-life (T1/2re) calculated by compound concentration of 7:3 FTCA and PFOA was longest in kidney tissue (8.60 and 23.9 d, respectively), while their absolute elimination half-life (T1/2ab) of 7:3 FTCA and PFOA calculated by compound amount was longest in kidney tissue (10.41 and 64.1 d, respectively). The T1/2re and T1/2ab for PFHpA was longest in heart tissue (19.3 d and 30.26 d, respectively).The accumulated PFOA in kidney and liver tissues was still above the detection limit (LOD) at 21 d postdosing. These results indicate that PFOA and the kidneys are the ideal biomonitoring marker and target tissue, respectively, for 8:2 FTOH pollution. The T1/2 values of the main metabolites were of long duration compared to the growth cycle of farmed pigs (approximately 180 d) before slaughter; therefore, pigs contaminated with 8:2 FTOH present a potential risk to humans.
Location:
Topics: