Tree barks for retrospective measurement and source appointment of airborne perfluoroalkyl and polyfluoroalkyl substances
16 Jan 2024 | Environ. Pollut.
Tree bark was found to be a valuable bioindicator for assessing airborne PFAS pollution, offering a long-term perspective on historical PFAS emissions and allowing for the characterization and tracking of sources, as demonstrated in a study of eight cities in southern Jiangsu Province, China.
Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6: 2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
16 Jan 2024 | FCT
Following oral exposure, both pregnant and nonpregnant rats exhibited potential biopersistence of 6:2 fluorotelomer alcohol (6:2 FTOH) and its metabolites, particularly 5:3 fluorotelomer carboxylic acid (5:3A), highlighting the need for additional research on human health implications.
Per/Polyfluoroalkyl Substances (PFASs) in a Marine Apex Predator (White Shark, Carcharodon carcharias) in the Northwest Atlantic Ocean
14 Jan 2024 | ACS Environmental Au
This study highlighted the accumulation of PFAS in plasma and muscle tissue of white sharks in the Northwest Atlantic Ocean far from pollution sources and noted some geographical differences in PFAS body burdens that may be due to differences in the diet among these distinct shark populations.
Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia
13 Jan 2024 | JNCI
Maternal exposure to certain PFAS during pregnancy, particularly MeFOSAA, is associated with an increased risk of childhood acute lymphoblastic leukemia, with notable connections to elevated levels of PFOS, suggesting a potential link between these environmental chemicals and the development of the most common childhood cancer.
Passive Sampler Derived Profiles and Mass Flows of Perfluorinated Alkyl Substances (PFASs) across the Fram Strait in the North Atlantic
10 Jan 2024 | Environ. Technol. Lett.
PFAS were found at different depths across the Fram Strait, showing long-range marine transport and suggesting that PFAS in the Arctic are governed by a feedback loop between the Atlantic and Arctic oceans as well as atmospheric transport.
Association of prenatal exposure to perfluorinated and polyfluoroalkyl substances with childhood neurodevelopment: A systematic review and meta-analysis
10 Jan 2024 | Ecotoxicol Environ Saf
A meta-analysis on prenatal exposure to PFAS suggests a sex-specific relationship, revealing that PFOS, PFOA, and PFHxS are associated with decreased performance IQ in boys but PFOS was linked to increased performance IQ in girls, while PFAS are linked to executive function impairments in children without a significant association with behavioral difficulties.
Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake
10 Jan 2024 | Toxics
This study exposed mice to a mixture of PFAS at levels equivalent to estimated daily human intake, revealing that even low concentrations of PFAS caused liver tissue changes and altered gene expression related to metabolism and cancer, emphasizing the need for thorough toxicity assessments of these persistent environmental contaminants.
Assessing potential human health and ecological implications of PFAS from leave-in dental products
3 Jan 2024 | Toxicol Ind Health
PFBA and PFOS were found in low levels in night guards with no detection in whitening trays, suggesting these dental products are unlikely to pose health concerns or contribute significantly to environmental PFAS exposure compared to exposure from food and water.
Binding of Per- and Polyfluoroalkyl Substances (PFAS) to Serum Proteins: Implications for Toxicokinetics in Humans
3 Jan 2024 | Environ Sci Technol
PFAS binding to major blood serum proteins is thought to affect toxicity, transport, and half-lives in the body. This study found shorter-chain PFAS showing a stronger binding to human serum albumin and longer-chain PFAS displaying a greater affinity for globulins, emphasizing the significance of understanding these interactions for more precise assessments of PFAS impact on human health in epidemiological studies.
Investigating the progression of preeclampsia through a comprehensive analysis of genes associated with per- and polyfluoroalkyl substances
2 Jan 2024 | Toxicol Mech Methods
Using advanced analysis of genetic data, researchers identified a potential link between PFAS and the risk of preeclampsia, suggesting that these environmental factors may play a role in the development of the disease, and highlighted six genes with diagnostic potential for preeclampsia.
Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
30 Dec 2023 | Sci Total Environ
Exposure to PFOS may disrupt early skin development by altering cell morphology, gene expression, and crucial signaling pathways, suggesting a potential link between PFAS exposure and congenital skin diseases during embryonic development.
Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs
28 Dec 2023 | Environ Sci Technol
PFAS levels in the liver correlated well with other organs, supporting the use of blood concentrations as a measure of PFAS exposure and suggesting the liver as the primary organ of PFAS retention, with minor variations observed in other organs.
Prenatal per- and polyfluoroalkyl substances exposure and gut microbiota of infants: A prospective cohort study
28 Dec 2023 | Ecotoxicol Environ Saf
In a study of 69 mother-child pairs, PFAS was associated with changes in the gut microbiota of infants, potentially linking these alterations to known health impacts later in life.
Per-and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
27 Dec 2023 | CGH
A connection was found between elevated PFAS levels and increased odds of Crohn’s disease and ulcerative colitis for up to 10 years prior to diagnosis, with both legacy and emerging PFAS chemicals implicated.
GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways
27 Dec 2023 | Chem Res Toxicol
GenX, a substitute for PFOA, was found to cause liver damage and disrupt lipid metabolism in mice even at low environmental concentrations when exposed to drinking water.