Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals
23 Nov 2021 | Environ Int
In a proof-of-concept study, PFOA exposure was found to disrupt the most sensitive stage of neuron development.
Perfluorooctane sulfonate (PFOS) induces several behavioural defects in Caenorhabditis elegans that can also be transferred to the next generations
23 Nov 2021 | Chemosphere
PFOS can exert severe neurobehavioral defects in locomotion, lifespan, and reproduction that can be transferred from parents to their offspring in a human model species.
The driving factors of per- and polyfluorinated alkyl substance (PFAS) accumulation in selected fish species: The influence of position in river continuum, fish feed composition, and pollutant properties
23 Nov 2021 | Sci Total Environ
Molecular mass and fluorine number play crucial roles in PFAS bioaccumulation in fish.
Per- and Polyfluoroalkyl Substances (PFAS): Significance and Considerations within the Regulatory Framework of the USA
23 Nov 2021 | Int J Environ Res Public Health
Regulatory agencies must start being proactive instead of reactive with PFAS contamination.
Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS
23 Nov 2021 | Chemosphere
Mechanisms of PFOA and PFOS immunotoxicity in humans and animals were summarized.
What difference can drop-in substitution actually make? A life cycle assessment of alternative water repellent chemicals
22 Nov 2021 | J. Clean. Prod.
A life cycle assessment found non-fluorinated durable water repellents for outdoor garments were environmentally preferable to fluorinated variants leading to the recommendation to phase out PFAS.
Per- and polyfluoroalkyl substances (PFASs) in airborne particulate matter (PM2.0) emitted during floor waxing: A pilot study
16 Nov 2021 | Atmos. Environ.
Significantly higher levels of PFAS were measured during floor waxing, potentially putting occupational workers at greater risk.
Biodegradation of per- and polyfluoroalkyl substances (PFAS): A review
16 Nov 2021 | Bioresour Technol
The biodegradation pathways for different types of subclasses of PFAS are summarized in two major categories, biodegradation with and without the cleavage of the C-F bond.
A New OECD Definition for Per- and Polyfluoroalkyl Substances
16 Nov 2021 | Environ Sci Technol
The Organisation for Economic Co-operation and Development and the United Nations Environment Programme expanded on their definition of PFAS to include fluorinated substances that contain at least one fully fluorinated methyl or methylene carbon atom.
Investigation of levels of perfluoroalkyl substances in freshwater fishes collected in a contaminated area of Veneto Region, Italy
16 Nov 2021 | Environ Sci Pollut Res Int
Consumption of fish more than once a month from a contaminated region of Italy might result in high exposure to PFAS.
Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression
9 Nov 2021 | Nutrients
PFOS exposure in conjunction with a high-fat diet may contribute to prostate cancer development and increase tumor aggressiveness.
Perfluorooctane sulfonate (PFOS) triggers migration and invasion of esophageal squamous cell carcinoma cells via regulation of Zeb1
9 Nov 2021 | Drug Chem Toxicol
Environmental exposure and body accumulation of PFOS might be an important risk factor for esophagus cancer progression, one of the most deadly cancers worldwide.
Short-term exposure to perfluorotetradecanoic acid affects the late-stage regeneration of Leydig cells in adult male rats
9 Nov 2021 | Toxicol Appl Pharmacol
The short-term exposure to PFTeDA during specific windows of sex cell regeneration was associated with reduced testosterone levels and lowered sperm counts in rats.
Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances
9 Nov 2021 | Biotechnol Bioeng
A novel method of detecting selected PFAS in water (at parts per billion or million levels) by using human liver proteins was developed and implemented in field applications.
Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach
9 Nov 2021 | Environ Int
Higher PFOA and PFNA blood levels in pregnant African American women were associated with reduced fetal growth.