The Dilemma of Perfluorooctanoate (PFOA) Human Half-life
25 Aug 2021 | Regul Toxicol Pharmacol
Based on information from both human observational studies and clinical data, we proposed a range for the half-life for PFOA of 0.5 to 1.5 years, which would likely raise many existing regulatory safe levels if all other parameters stayed the same.
External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications
25 Aug 2021 | Environ Int
PFAS were detected in human hair, and their compositions were similar to those in human serum, suggesting that hair is a good non-invasive indicator for long-term exposure to legacy long-chain perfluoroalkyl carboxylic acids and HFPOs.
Perfluoroalkyl substances (PFAS) in drinking water and risk for polycystic ovarian syndrome, uterine leiomyoma, and endometriosis: A Swedish cohort study
25 Aug 2021 | Environ Int
Exposure to high levels of PFAS in drinking water was associated with an increased risk of enlarged and irritated ovaries.
Chlorinated polyfluoroalkyl ether sulfonic acids in fish, dust, drinking water and human serum: From external exposure to internal doses
25 Aug 2021 | Environ Int
The modeled serum concentrations of 6:2 Cl-PFESA were higher than its observed levels hinting at its gradually increasing exposure levels in the general population.
Removal of per- and poly-fluoroalkyl substances (PFASs) by wetlands: Prospects on plants, microbes and the interplay
25 Aug 2021 | Sci Total Environ
The choice of plants and bacterial species is however crucial for the bioremediation of PFAS, and the system efficiency relies on species-specific, sediment-specific, and pollutant-specific principles.
Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy: The HOME Study
25 Aug 2021 | Environ Int
HFPO-DA was found to potentially be a major problem of health risk that affects inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals.
Correlates of plasma concentrations of per- and poly-fluoroalkyl substances among reproductive-aged Black women
24 Aug 2021 | Environ Res
PFAS exposure was strongly associated with reproductive factors such as reduced concentrations with parity, recent birth, lactation, and heavy menstrual bleeding in black women.
Perfluorinated compounds disrupted osmoregulation in Oryzias melastigma during acclimation to hypoosmotic environment
18 Aug 2021 | Ecotoxicol Environ Saf
PFOS showed a greater impact on fish’s ability to extract oxygen from fresh and saltwater than the shorter chain homolog PFBS.
Perfluorooctane sulfonate (PFOS) disturbs fatty acid metabolism in Caenorhabditis elegans: Evidence from chemical analysis and molecular mechanism exploration
17 Aug 2021 | Chemosphere
PFOS was found to inhibit energy synthesis during fatty acid metabolism in a model species.
Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects in murine intestinal tissue.
17 Aug 2021 | Scand J Gastroenterol
PFAS was found to irritate the intestinal tract leading to inflammatory bowel disease later in life.
Associations of Prenatal Exposure to Per- and Polyfluoroalkyl Substances with the Neonatal Birth Size and Hormones in the Growth Hormone/Insulin-Like Growth Factor Axis
17 Aug 2021 | Environ Sci Technol
High levels of PFAS mixtures were associated with lower birth weights.
Harnessing electronic health records to study emerging environmental disasters: a proof of concept with perfluoroalkyl substances (PFAS)
17 Aug 2021 | NPJ Digit Med
Using only electronic health records researchers were able to properly predict the health outcomes of a PFAS contaminated zone.
PFASs intake from fish, eggs and drinking water in Greece in relation to the safety limits for weekly intake proposed in the EFSA scientific opinion of 2020
17 Aug 2021 | Chemosphere
The total exposure levels of PFOA, PFOS, PFNA, and PFHxS exceeded legal limits for fish and egg consumption.
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice
17 Aug 2021 | Sci Total Environ
PFHxA exposure was linked with oxidative stress in the liver by inhibition of purine and glutathione metabolism.
Investigation of distribution, sources and flux of perfluorinated compounds in major southern Indian rivers and their risk assessment
17 Aug 2021 | Chemosphere
Seasonal fluxes of PFAS concentrations were found throughout India with levels ranging from non-detect to 10,545 pg/l.