The use of in vitro methods in assessing human health risks associated with short-chain perfluoroalkyl and polyfluoroalkyl substances (PFAS)
13 Dec 2021 | J Appl Toxicol
This review summarizes the PFAS toxicity data obtained using human cells in vitro, discusses the advantages and limitations of cell-based models, and provides thoughts on potential solutions to the challenges of these methods.
PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets and in mouse lung tissues
12 Dec 2021 | Toxicol Rep
PFOA was found to change gene expression in lungs, potentially increasing susceptibility to COVID-19.
Tumorigenic activity of alternative per- and polyfluoroalkyl substances (PFAS): Mechanistic in vitro studies
6 Dec 2021 | Sci Total Environ
PFHxS has been associated with breast cancer in epidemiological studies, and this study demonstrated how this shorter-chain PFAS can affect cell proteins and cell proliferation.
Exposure of male mice to perfluorooctanoic acid induces anxiety-like behaviors by increasing corticotropin-releasing factor in the basolateral amygdala complex
6 Dec 2021 | Chemosphere
PFOA exposure in mice led to a metabolic cascade of effects resulting in anxiety-like behaviors.
Perfluorooctane sulfonate (PFOS) exposure of bovine oocytes affects early embryonic development at human-relevant levels in an in vitro model
6 Dec 2021 | Toxicology
Human-relevant levels of PFOS alter early bovine embryo development in vitro.
In Vivo Transformation of a Novel Polyfluoroether Surfactant
6 Dec 2021 | Environ Toxicol Chem
Rats that received a novel PFAS surfactant orally rather than intravenously had higher breakdown products in their blood suggesting the importance of metabolism in the gut and liver.
Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats
6 Dec 2021 | Exp Ther Med
Exposure to PFOS left rats with heart inflammation and other markers of cardiac toxicity.
Prenatal exposure to poly-/per-fluoroalkyl substances is associated with alteration of lipid profiles in cord-blood
30 Nov 2021 | Metabolomics
Prenatal PFAS exposure may explain associations between PFAS exposure and adverse health conditions later in life, such as type 2 diabetes.
Poly- and Perfluorinated Alkyl Substances in Air and Water from Dhaka, Bangladesh.
30 Nov 2021 | Environ Toxicol Chem
The prevalence of 6:2 FTOH and PFBA across sites likely reflects their usage in textile manufacturing and could indicate the industry's switch to shorter chain PFAS.
Impaired gross motor development in infants with higher PFAS concentrations
30 Nov 2021 | Environ Res
Maternal fish intake determined infant PFAS levels and was associated with poorer infant gross motor development.
Exposure to perfluoroalkyl substances was associated with estrogen homeostasis in pregnant women
30 Nov 2021 | Sci Total Environ
Exposure to PFAS disturbed hormone levels in pregnant women and the effects varied with the time periods of exposure during pregnancy.
PFASs pollution in Galveston Bay surface waters and biota (shellfish and fish) following AFFFs use during the ITC fire at Deer Park (March 17th-20th 2019), Houston, TX
30 Nov 2021 | Sci Total Environ
High PFAS levels were measured in water following AFFF usage on a nearby petrochemical fire and a risk assessment suggested a fish consumption advisory to protect against human exposure.
Species- and Tissue-Specific Chronic Toxicity Values for Northern Bobwhite Quail (Colinus virginianus) Exposed to PFHxA and a Binary Mixture of PFOS and PFHxA
30 Nov 2021 | Environ Toxicol Chem
PFHxA was more toxic to reproducing birds than either PFOS or a PFOS:PFHxS mixture, suggesting that avian PFAS toxicity is not necessarily additive.
Distribution and ten-year temporal trends (2009-2018) of perfluoroalkyl substances in gull eggs from Spanish breeding colonies
30 Nov 2021 | Environ Pollut
Total PFAS concentrations in gull eggs decreased through the 10-year study period in all but one colony, highlighting the usefulness of gull eggs as bioindicators of PFAS pollution in water and fish.
Distribution, source identification and health risk assessment of PFASs in groundwater from Jiangxi Province, China
30 Nov 2021 | Chemosphere
Monitoring in China suggests that PFBA, PFPeA, 6:2 FTS and F–53B are broadly used replacements of PFOA and PFOS with estimated daily intakes of short-chain PFCAs higher than that of PFOA.