Showing 271-285 of 552
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Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview
Science
15 Feb 2022 | Environ Int
A review of a novel PFAS demonstrated hepatotoxicity, endocrine disruption, reproductive, and developmental toxicity, and suggested further research given the extreme biopersistence of F-53B.
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Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes
Science
15 Feb 2022 | Chemosphere
All tested placenta samples contained detectable PFAS, including PFOS, PFOA, PFNA, and PFDA in >96% samples, and placental PFOS was associated with lower birth weight for in male infants and higher birth weight in female infants.
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Per- and polyfluoroalkyl substances in the environment
Science
7 Feb 2022 | Science
This review summarizes the sources, transport, degradation, and toxicological implications of the megatonne of PFAS produced yearly, highlighting the importance of investigating potential PFAS replacements, the importance of lifecycle considerations, and that PFAS remediation efforts are still in their infancy.
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Gestational exposure to GenX induces hepatic alterations by the gut-liver axis in maternal mice: A similar mechanism as PFOA
Science
1 Feb 2022 | Sci Total Environ
Gestational exposure to PFOA or GenX induced similar disease indicator changes in maternal livers.
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Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population
Science
1 Feb 2022 | Environ Res
PFOA, PFNA, and PFDA were inversely related to fat mass measurements in women but not men, while PFOS and PFHxS had no consistent associations with body composition.
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Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Science
1 Feb 2022 | Environ Health Perspect
Prenatal PFAS exposure might influence the development of fetus heads and faces, especially when coupled with alcohol consumption.
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PFAS Molecules: A Major Concern for the Human Health and the Environment
Science
25 Jan 2022 | Toxics
This review summarizes the current knowledge on PFAS chemistry uses, occurrence, and environmental fate, with a particular emphasis on effects on humans as well as an analysis of the European Union’s efforts to regulate and remediate PFAS.
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Sulfonamide Functional Head on Short-Chain Perfluorinated Substance Drives Developmental Toxicity
Science
25 Jan 2022 | iScience
FBSA exposure leads to changes in DNA that result in abnormal body structure and disrupted gene expression in human model species.
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Demographic, life-style and physiological determinants of serum per- and polyfluoroalkyl substance (PFAS) concentrations in a national cross-sectional survey of Swedish adolescents
Science
17 Jan 2022 | Environ Res
Legacy PFAS were found at elevated levels throughout Swedish adolescents in addition to the novel 9Cl-PF3ONS in 5% of those tested, and females had lower serum PFAS concentration than males.
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Exposure to perfluorooctanoic acid leads to promotion of pancreatic cancer
Science
16 Jan 2022 | Carcinogenesis
PFOA was found to potentially promote pancreatic cancer progression in a mice model.
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Quantitation of linear and branched perfluoroalkane sulfonic acids (PFSAs) in women and infants during pregnancy and lactation
Science
10 Jan 2022 | Environ Int
A linear relation between PFSA concentrations in mothers at pregnancy week 18 and infants at six months was observed, suggesting that pregnancy and lactation are major excretion routes for PFSA, but accumulate in the infant.
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Characterization of Per- and Polyfluorinated Alkyl Substances Present in Commercial Anti-fog Products and Their Adipogenic Activity
Science
10 Jan 2022 | Environ Sci Technol
High concentrations of PFAS were detected in all measured anti-fog products, with FTEOs found to be a significant contributor to the adipogenic activity exhibited by the anti-fog sprays.
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US EPA turns down requests for more PFAS toxicity testing
Policy
30 Dec 2021
The US EPA has deferred or turned down advocacy groups’ requests to require Chemours to conduct toxicity tests on dozens of fluorochemicals found in North Carolina drinking water supplies.
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Environmental pollutant exposure associated with altered early-life gut microbiome: Results from a birth cohort study
Science
20 Dec 2021 | Environ Res
Prenatal exposure to PFAS is associated with alterations to gut microbiome development in infants, with larger effects in breastfed and cesarean-section-born babies.
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Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan
Science
20 Dec 2021 | Reprod Toxicol
Maternal PFOS exposure was linked with decreased female infant size.