Showing 46-60 of 538
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6: 2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound
Science
16 Jan 2024 | FCT
Following oral exposure, both pregnant and nonpregnant rats exhibited potential biopersistence of 6:2 fluorotelomer alcohol (6:2 FTOH) and its metabolites, particularly 5:3 fluorotelomer carboxylic acid (5:3A), highlighting the need for additional research on human health implications.
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Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia
Science
13 Jan 2024 | JNCI
Maternal exposure to certain PFAS during pregnancy, particularly MeFOSAA, is associated with an increased risk of childhood acute lymphoblastic leukemia, with notable connections to elevated levels of PFOS, suggesting a potential link between these environmental chemicals and the development of the most common childhood cancer.
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Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
Science
30 Dec 2023 | Sci Total Environ
Exposure to PFOS may disrupt early skin development by altering cell morphology, gene expression, and crucial signaling pathways, suggesting a potential link between PFAS exposure and congenital skin diseases during embryonic development.
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Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs
Science
28 Dec 2023 | Environ Sci Technol
PFAS levels in the liver correlated well with other organs, supporting the use of blood concentrations as a measure of PFAS exposure and suggesting the liver as the primary organ of PFAS retention, with minor variations observed in other organs.
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Prenatal per- and polyfluoroalkyl substances exposure and gut microbiota of infants: A prospective cohort study
Science
28 Dec 2023 | Ecotoxicol Environ Saf
In a study of 69 mother-child pairs, PFAS was associated with changes in the gut microbiota of infants, potentially linking these alterations to known health impacts later in life.
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Per-and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
Science
27 Dec 2023 | CGH
A connection was found between elevated PFAS levels and increased odds of Crohn’s disease and ulcerative colitis for up to 10 years prior to diagnosis, with both legacy and emerging PFAS chemicals implicated.
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Prenatal Exposure to Poly- and Perfluoroalkyl Substances (2009-2014) and Vaccine Antibody Titers of Measles, Mumps, Rubella, and Varicella in Children Four to Eight Years Old from the Healthy Start Cohort
Science
26 Dec 2023 | Environ Health Perspect
Prenatal exposure to PFAS is linked to lower antibody levels in fully immunized children, particularly for measles and mumps, suggesting potential immunotoxic effects.
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Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses
Science
25 Dec 2023 | Medical Research Archives
This perspective outlines PFAS hepatoxicity, suggesting practical clinician responses to address patient and community needs, and emphasizing strong evidence of PFAS causing adverse changes in human liver biomarkers.
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Firefighters' exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review.
Science
18 Dec 2023 | Front Mater
The close link between firefighters and cancer may be partly driven by occupational exposure to carcinogenic PFAS found in turnout gear, firefighting foam, and fire station environments leading to elevated PFAS levels in firefighters’ blood serum.
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First insights into per-and polyfluoroalkyl substance contamination in edible fish species of the Indus water system of Pakistan
Science
17 Dec 2023 | Chemosphere
The study investigated the contamination of edible fish in major tributaries of the Indus System andfound high levels of PFAS, in certain fish species from areas with poor wastewater treatment in Pakistan, highlighting potential environmental and health concerns, and suggesting the need for ongoing monitoring and research into the bioaccumulation patterns of PFAS.
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Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study
Science
13 Dec 2023 | Environ Sci Technol
Prenatal exposure to a mixture of PFAS in mothers is linked to alterations in infant metabolic pathways, which can result in birthweight or vaccine response abnormalities.
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[Press Release] Kildee Introduces New Bipartisan Legislation To Improve Medical Treatment For PFAS-Exposed Patients
Policy
7 Dec 2023
Congressman Dan Kildee, co-chair of the bipartisan Congressional PFAS Task Force, and Congressman Mike Lawler today introduced bipartisan legislation, supported by Republicans and Democrats, to ensure doctors have up-to-date information on how best to treat patients exposed to toxic PFAS.
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Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva
Science
6 Dec 2023 | Environ Health Perspect
Prenatal exposure to PFAS impacted the body weight and composition of teenagers, finding that higher concentrations of these substances were associated with an increased risk of obesity and altered BMI trajectories during late adolescence.
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Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study
Science
2 Dec 2023 | IJO
Exposure to PFAS during pregnancy was found to be associated with increased body mass in early childhood, particularly in terms of precisely measured fat mass, emphasizing potential health implications for children exposed to PFAS during gestation.
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Prenatal exposure to Per-and polyfluoroalkyl substances and adiposity measures of children at 4 and 6 years: A prospective birth cohort in China
Science
1 Dec 2023 | Ecotoxicol Environ Saf
Exposure to PFAS during pregnancy was linked to increased adiposity in Chinese children at ages 4 and 6, with a stronger impact on measures like arm circumference and waist circumference, particularly among girls.