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• Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain

  Science

  8 Sep 2021 | Environ Res

  PFAS, including short chains, were found inside the brain circumnavigating the blood-brain barrier.

• The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure

  Science

  8 Sep 2021 | Toxicology

  PFAS mixtures were found to have increased detrimental effects, especially when transferred from mother to offspring.

• Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model

  Science

  8 Sep 2021 | Food Chem Toxicol

  Sustained dermal exposure to PFBA induces liver toxicity and raises concerns of short-chain PFAS being promoted as safer alternatives.

• Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth

  Science

  8 Sep 2021 | Environ Health Perspect

  Youth exposure to PFHxS was associated with abnormal metabolism in females, especially after puberty.

• Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids

  Science

  8 Sep 2021 | Toxicol Sci

  Longer-chain compounds (7 to 10 carbons) were more likely to induce changes in gene expression.

• FDA Releases PFAS Testing Results from First Survey of Nationally Distributed Processed Foods

  Policy

  1 Sep 2021

  The U.S. Food and Drug Administration released the first survey of PFAS in nationally distributed processed foods, including several processed baby foods.

• Per/polyfluoroalkyl substances production, applications and environmental impacts

  Science

  31 Aug 2021 | Bioresource Tech.

  Current chemical and biological remediation technologies are expensive/not effective and thus new remediation technologies must be developed.

• Rapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE-UPLC-MS/MS

  Science

  31 Aug 2021 | Toxics

  A new analytical method was optimized for use on mammalian tissues with up to 89% detection.

• Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice

  Science

  31 Aug 2021 | Environ Pollut

  Potential gut toxicity of HFPO-DA and is perceived as a major problem of health risk that affects inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals.

• Early pregnancy loss: Do Per- and polyfluoroalkyl substances matter?

  Science

  31 Aug 2021 | Environ Int

  Overall, we suggest that most PFAS were not associated with early pregnancy loss at the current exposure levels.

• Analysis of per- and poly-fluoroalkyl substances (PFAS) in processed foods from FDA's Total Diet Study

  Science

  31 Aug 2021 | Anal Bioanal Chem

  PFAS features detected by LC-MS/MS correlated well in abundance with LC-IMS-MS data; however, LC-IMS-MS identified a number of additional PFAS, many known to be components of firefighting foams.

• Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study

  Science

  31 Aug 2021 | Int J Environ Res Public Health

  PFOA and PFOS were positively associated with developing cardiovascular diseases and their risk factors.

• Perfluorobutanoic acid (PFBA): No high-level accumulation in human lung and kidney tissue

  Science

  30 Aug 2021 | Int J Hyg Environ Health

  Contrary to previous findings, analysis of short-chain PFAS in human lungs and kidney indicates PFBA is not likely to accumulate in these tissues.

• 2nd Stakeholder Consultation on a Restriction for PFAS

  Policy

  25 Aug 2021

  The competent authorities for REACH of the Netherlands, Germany, Denmark, Sweden, and Norway are currently preparing a REACH Annex XV Restriction Dossier for the group of PFAS since all these substances are considered to be persistent.

• The occurrence of per- and polyfluoroalkyl substances (PFASs) in fluoropolymer raw materials and products made in China

  Science

  25 Aug 2021 | J Environ Sci (China)

  Generally, the levels of PFOA in raw materials were higher than in products, implying that PFOA in the emulsion/dispersion resin could be partly removed during the polymerization or post-processing steps.