Showing 226-240 of 250
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Toxicokinetics and persistent thyroid hormone disrupting effects of chronic developmental exposure to chlorinated polyfluorinated ether sulfonate in Chinese rare minnow
Science
7 Apr 2020 | Environ. Poll.
Thyroid hormones and gene regulation remained at disturbed levels in adult fish, due to PFAS exposure.
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Metabolic and Pharmaceutical Aspects of Fluorinated Compounds
Science
24 Mar 2020 | J of Medi. Chem.
A review of the literature associated with the metabolism of fluorinated molecules, focusing on examples where the presence of fluorine influences the metabolic profile.
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Interaction between hypoxia and perfluorobutane sulfonate on developmental toxicity and endocrine disruption in marine medaka embryos
Science
17 Mar 2020 | Aq. Tox.
PFBS found to disrupt development and the endocrine system of juvenile fish.
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Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks
Science
11 Mar 2020 | Toxicol Pathol
GenX found to change liver function through interruption of receptors such as PPARα.
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Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet β Cells via G Protein-Coupled Receptor 40
Science
3 Mar 2020 | Environ. Sci. Technol.
Evidence for a novel mechanism for how PFASs disrupt insulin-secretion in a human was discovered.
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Per- and Polyfluoroalkyl Substances: An Emerging Contaminant of Concern
Science
2 Mar 2020 | Ann. Rev. of Nur. Res.
This chapter discusses the health harm associated with PFAS, exposure and risk reduction, advisory levels, and medical testing/management.
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Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants
Science
3 Feb 2020 | ALTEX
Researchers used computers to predict the toxicity of persistent organic pollutants such as PFAS.
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‘Our voices are not being heard’: Colorado town a test case for California PFAS victims
News
31 Jan 2020 | Los Angeles Times
When Wendy Rash was diagnosed in 2005 with a thyroid disorder, chronic fatigue and other ailments, her doctor couldn’t explain her suddenly failing health. It wasn’t until 2016 that scientists tested the tap water they had been drinking and found it was contaminated with man-made chemicals known as per-fluorinated compounds.
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The emerging PFOS alternative OBS exposure induced gut microbiota dysbiosis and hepatic metabolism disorder in adult zebrafish
Science
16 Jan 2020 | Comp. Biochem. Physiol. C Toxicol. Pharmacol.
The PFAS alternative, sodium ρ-perfluorous nonenoxybenzene sulfonate, was found to change gut bacteria levels and negatively impact metabolism.
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Immunotoxicity and allergenic potential induced by topical application of perfluorooctanoic acid (PFOA) in a murine model
Science
16 Jan 2020 | Food Chem. Toxicol.
PFOA was found to be toxic to the immune system through skin exposure.
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Prenatal exposure to perfluorodecanoic acid is associated with lower circulating concentration of adrenal steroid metabolites during mini puberty in human female infants. The Odense Child Cohort
Science
13 Jan 2020 | Environ. Res.
High prenatal exposure to PFDA associated with decreased hormone production in babies.
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Quantitative bias analysis of the association between subclinical thyroid disease and two perfluoroalkyl substances in a single study
Science
25 Dec 2019 | Environ. Res.
A physiologically based pharmacokinetic model was used to quantify bias in a reported PFAS-thyroid association.
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Altered expression and activity of phase I and II biotransformation enzymes in human liver cells by perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS)
Science
10 Dec 2019 | Toxicology
PFOA and PFOS found to inhibit the body's ability to breakdown and absorb nutrients.
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Topic of Cancer: How PFAS threaten our water
News
10 Dec 2019 | Capital & Main
What’s more, while the persistent and mobile nature of PFAS chemicals means that no neighborhood is safe from contamination, smaller water systems—particularly those serving disadvantaged communities—face an uphill task in tackling the problem due to the higher probability of aging infrastructure and limited resources, as compared to larger utilities.
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Top U.S. toxicologist was barred from saying PFAS cause disease in humans. She’s saying it now
News
24 Oct 2019 | The Intercept
“I was banned from doing it,” said Birnbaum. “I had to use ‘association’ all the time. If I was talking about human data or impacts on people, I had to always say there was an association with a laundry list of effects.”