Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food

13 Apr 2021 | Int J Environ Res Public Health

PFAS show weak or no activity in immune-related ToxCast assays, which differs from traditional toxicological studies.

Biological and behavioural responses of European honey bee (Apis mellifera) colonies to perfluorooctane sulfonate (PFOS) exposure

12 Apr 2021 | Integr Environ Assess Manag

PFOS exposure adversely affects honey bee colonies and may transfer to honey.

The interplay between environmental exposures and COVID-19 risks in the health of children

7 Apr 2021 | Env. Health

An international group of researchers interested in children’s environmental health was invited to identify knowledge gaps and to develop research questions to close these gaps.

Considerations for Toxicity Experiments and Risk Assessments with PFAS Mixtures

7 Apr 2021 | IEAM

This perspective article discusses available approaches for mixtures risk assessment with a specific focus on application to PFAS mixtures.

Exploring Unknown Per- and Polyfluoroalkyl Substances in the German Environment – the Total Oxidizable Precursor Assay as Helpful Tool in Research and Regulation

7 Apr 2021 | Sci. Total Environ.

Time trend analysis showed decreasing trends for most detected PFAS since 2005 with the results demonstrating that target analysis detects only a minor fraction of the PFAS burdens in environmental samples.

PFAS accumulation in indigenous and translocated aquatic organisms from Belgium, with translation to human and ecological health risk

7 Apr 2021 | Environ. Sci. Eur.

In mussels, PFAS profiles were dominated by PFOA and showed a higher relative contribution of short-chained PFAS, while PFAS profiles in fish were dominated by PFOS.

Human exposure pathways to poly- and perfluoroalkyl substances (PFAS) from indoor media: A systematic review protocol

7 Apr 2021 | Environ. Int

An adapted protocol was developed to utilize existing systematic review tools for exposure science questions concerning PFAS.

Per- and Polyfluoroalkyl Substance (PFAS) Transport from Groundwater to Streams near a PFAS Manufacturing Facility in North Carolina, USA

7 Apr 2021 | Environ Sci Technol

The mass transfer between groundwater and surface water of PFAS was quantified for contaminated communities.

Acute Toxicity and Trans-Generational Effects of Perfluorobutane Sulfonate (PFBS) in Caenorhabditis elegans

7 Apr 2021 | Environ Toxicol Chem

Chronic exposure to PFBS at higher concentrations can cause behavioral toxicity and could be transferred to offspring in human model species.

Occurrence of per- and polyfluoroalkyl substances and unidentified organofluorine in leachate from waste-to-energy stockpile - A case study

6 Apr 2021 | Chemosphere

Short-chain PFASs were dominant in leachate from a Waste-to-Energy stockpile with 88% extractable organofluorine coming from unidentified substances.

Perfluoroalkyl substance excretion: Effects of organic anion-inhibiting and resin-binding drugs in a community setting

6 Apr 2021 | Environ. Toxicol. Pharmacol.

Bile acids were found to lower serum PFAS concentrations significantly.

Advancing per- and polyfluoroalkyl substances (PFAS) research: an overview of ATSDR and NCEH activities and recommendations

6 Apr 2021 | Journal of Exposure Science and Environmental Epidemiology

This paper presents a framework, compelling questions, and research activities to help NCEH and ATSDR advance scientific discovery in partnership with federal, state, and local stakeholders as part of a comprehensive public health response to PFAS contamination.

A Fresh Look at Stress and Resilience in Communities Affected by Environmental Contamination

5 Apr 2021 | Journal of Environmental Health

A perspective on the stress related to living in a contaminated community.

Considering Environmental Exposures to Per- and Polyfluoroalkyl Substances (PFAS) as Risk Factors for Hypertensive Disorders of Pregnancy.

3 Apr 2021 | Environ Res

Pregnant women may be a group that is vulnerable to hypertensive disorders associated with PFAS exposures which should be considered by policymakers setting PFAS exposure limits.