Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
30 Dec 2023 | Sci Total Environ
Exposure to PFOS may disrupt early skin development by altering cell morphology, gene expression, and crucial signaling pathways, suggesting a potential link between PFAS exposure and congenital skin diseases during embryonic development.
Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs
28 Dec 2023 | Environ Sci Technol
PFAS levels in the liver correlated well with other organs, supporting the use of blood concentrations as a measure of PFAS exposure and suggesting the liver as the primary organ of PFAS retention, with minor variations observed in other organs.
Prenatal per- and polyfluoroalkyl substances exposure and gut microbiota of infants: A prospective cohort study
28 Dec 2023 | Ecotoxicol Environ Saf
In a study of 69 mother-child pairs, PFAS was associated with changes in the gut microbiota of infants, potentially linking these alterations to known health impacts later in life.
Per-and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
27 Dec 2023 | CGH
A connection was found between elevated PFAS levels and increased odds of Crohn’s disease and ulcerative colitis for up to 10 years prior to diagnosis, with both legacy and emerging PFAS chemicals implicated.
GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways
27 Dec 2023 | Chem Res Toxicol
GenX, a substitute for PFOA, was found to cause liver damage and disrupt lipid metabolism in mice even at low environmental concentrations when exposed to drinking water.
Prenatal Exposure to Poly- and Perfluoroalkyl Substances (2009-2014) and Vaccine Antibody Titers of Measles, Mumps, Rubella, and Varicella in Children Four to Eight Years Old from the Healthy Start Cohort
26 Dec 2023 | Environ Health Perspect
Prenatal exposure to PFAS is linked to lower antibody levels in fully immunized children, particularly for measles and mumps, suggesting potential immunotoxic effects.
Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses
25 Dec 2023 | Medical Research Archives
This perspective outlines PFAS hepatoxicity, suggesting practical clinician responses to address patient and community needs, and emphasizing strong evidence of PFAS causing adverse changes in human liver biomarkers.
Comparison of the PFAS and physical-chemical parameter fluctuations between an ash landfill and a MSW landfill
22 Dec 2023 | Waste Manag
PFAS levels in municipal solid waste and incinerator ash landfillswere found to be higher in solid waste leachate, suggesting the importance of considering these differences when designing leachate management systems for different landfill types.
Firefighters' exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review.
18 Dec 2023 | Front Mater
The close link between firefighters and cancer may be partly driven by occupational exposure to carcinogenic PFAS found in turnout gear, firefighting foam, and fire station environments leading to elevated PFAS levels in firefighters’ blood serum.
First insights into per-and polyfluoroalkyl substance contamination in edible fish species of the Indus water system of Pakistan
17 Dec 2023 | Chemosphere
The study investigated the contamination of edible fish in major tributaries of the Indus System andfound high levels of PFAS, in certain fish species from areas with poor wastewater treatment in Pakistan, highlighting potential environmental and health concerns, and suggesting the need for ongoing monitoring and research into the bioaccumulation patterns of PFAS.
Unregulated Active and Closed Textile Mills Represent a Significant Vector of PFAS Contamination into Coastal Rivers
15 Dec 2023 | ACS ES&T Water
Sampling of rivers downstream from textile miles revealed higher concentrations of PFOS and PFCAs, demonstrating that both closed and active mills are important ongoing sources of PFAS to freshwater and marine regions.
Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines
14 Dec 2023 | Environ Health
Exposure to PFAS may induce chemotherapy resistance or enhance therapeutic efficacy in some cancer cells by affecting the cells' energy synthesis capabilities in both cases.
Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study
13 Dec 2023 | Environ Sci Technol
Prenatal exposure to a mixture of PFAS in mothers is linked to alterations in infant metabolic pathways, which can result in birthweight or vaccine response abnormalities.
In vitro screening of per-and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays
10 Dec 2023 | Toxicology in Vitro
85 of 136 tested PFAS affected key molecular events in the thyroid and endocrine hormone system, potentially resulting in associated health and ecological effects.
[Perspective] Global Perspective on the Impact of Plastic Waste as a Source of Microplastics and Per-and Polyfluoroalkyl Substances in the Environment
8 Dec 2023 | ACS ES&T Water
Microplastics (MPs) and PFAS in the environment pose a serious threat to ecosystems and MPs act as carriers for PFAS, creating a secondary source of pollution–highlighting the need to better understand this interaction.