Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
8 Sep 2021 | Environ Int
Exposure of mice to a mixture of PFAS results in abnormal modulation of cholesterol levels leading to increased liver weight and inflammation.
Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model
8 Sep 2021 | Food Chem Toxicol
Sustained dermal exposure to PFBA induces liver toxicity and raises concerns of short-chain PFAS being promoted as safer alternatives.
The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure
8 Sep 2021 | Toxicology
PFAS mixtures were found to have increased detrimental effects, especially when transferred from mother to offspring.
Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain
8 Sep 2021 | Environ Res
PFAS, including short chains, were found inside the brain circumnavigating the blood-brain barrier.
Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids
8 Sep 2021 | Toxicol Sci
Longer-chain compounds (7 to 10 carbons) were more likely to induce changes in gene expression.
PFAS and potential adverse impacts on bone and adipose tissue through interactions with PPAR-gamma
8 Sep 2021 | Endocrinology
PFAS was found to affect cell differentiation and bone development in several human model species.
Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
7 Sep 2021 | Environ Health
Positive associations between PFAS and telomere length in women workers, with larger effects seen among firefighters as compared to office workers.
Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha
4 Sep 2021 | Environ Pollut
Exposure to HFPO-DA induced developmental cardio-toxicity and hepatotoxicity in hatchling chickens similar to PFOA
The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid
2 Sep 2021 | Chemosphere
PFBS exposures were found to alter egg and embryo development, when exposure occurs preconception.
Per/polyfluoroalkyl substances production, applications and environmental impacts
31 Aug 2021 | Bioresource Tech.
Current chemical and biological remediation technologies are expensive/not effective and thus new remediation technologies must be developed.
Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort
31 Aug 2021 | Environ Res
Childhood concentrations of PFASs were associated with decreased regulation of appetite and fat storage.
Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice
31 Aug 2021 | Environ Pollut
Potential gut toxicity of HFPO-DA and is perceived as a major problem of health risk that affects inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals.
Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study
31 Aug 2021 | Int J Environ Res Public Health
PFOA and PFOS were positively associated with developing cardiovascular diseases and their risk factors.
Rapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE-UPLC-MS/MS
31 Aug 2021 | Toxics
A new analytical method was optimized for use on mammalian tissues with up to 89% detection.
Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice
31 Aug 2021 | Environ Sci Technol
The inhibition of nutrient absorption may be a prominent adverse effect induced by exposure to GenX, its analogs, and PFOA.