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• Harnessing electronic health records to study emerging environmental disasters: a proof of concept with perfluoroalkyl substances (PFAS)

  Science

  14 Sep 2021 | NPJ Digit Med

  This proof-of-concept study confirms that health records can be used to study human health and disease impacts of environmental disasters and produces equivalent disease-exposure knowledge to prospective epidemiology studies while remaining cost-effective.

• Can Environmental Law Solve the 'Forever Chemical' Problem?

  Science

  14 Sep 2021 | Wake Forest Law Review, Forthcoming

  A proposal away from the reactive toxicity honor system in favor of a precautionary approach to environmental protection.

• Temporal trends of perfluoroalkyl substances in an Australian wastewater treatment plant: A ten-year retrospective investigation

  Science

  14 Sep 2021 | Sci. Tot. Env.

  PFBA and 5:3 FTCA showed increasing concentrations between 2010 and 2020 with over 50% coming from industrial inputs.

• Comparative characterization of microbial communities that inhabit PFAS-rich contaminated sites: A case-control study

  Science

  14 Sep 2021 | J Hazard Mater

  Soil microbial communities were found to have adverse reactions to PFAS which may put crops at risk.

• Evaluation of the acute toxicity and neurodevelopmental inhibition of perfluorohexanoic acid (PFHxA) in zebrafish embryos

  Science

  14 Sep 2021 | Ecotoxicol Environ Saf

  High levels of PFHxA exposure was associated with permanent neurological damage in a human model organism.

• Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts.

  Science

  14 Sep 2021 | Environ Int

  Prenatal, rather than postnatal, PFAS exposure might contribute to increased obesity in children.

• Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk

  Science

  14 Sep 2021 | Environ Int

  Maternal exposure to PFAS impacts the nutritional quality of breast milk, which, in turn, may have a detrimental impact on the health and growth of the children later in life.

• Transport and environmental risks of perfluoroalkyl acids in a large irrigation and drainage system for agricultural production

  Science

  11 Sep 2021 | Environ Int

  Up to 40% of tolerant daily intake came from humans eating contaminated aquatic organisms.

• Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model

  Science

  8 Sep 2021 | Food Chem Toxicol

  Sustained dermal exposure to PFBA induces liver toxicity and raises concerns of short-chain PFAS being promoted as safer alternatives.

• PFAS and potential adverse impacts on bone and adipose tissue through interactions with PPAR-gamma

  Science

  8 Sep 2021 | Endocrinology

  PFAS was found to affect cell differentiation and bone development in several human model species.

• Exposure to Perfluoroalkyl Substances and Glucose Homeostasis in Youth

  Science

  8 Sep 2021 | Environ Health Perspect

  Youth exposure to PFHxS was associated with abnormal metabolism in females, especially after puberty.

• Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury

  Science

  8 Sep 2021 | Environ Int

  Exposure of mice to a mixture of PFAS results in abnormal modulation of cholesterol levels leading to increased liver weight and inflammation.

• The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure

  Science

  8 Sep 2021 | Toxicology

  PFAS mixtures were found to have increased detrimental effects, especially when transferred from mother to offspring.

• Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain

  Science

  8 Sep 2021 | Environ Res

  PFAS, including short chains, were found inside the brain circumnavigating the blood-brain barrier.

• Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids

  Science

  8 Sep 2021 | Toxicol Sci

  Longer-chain compounds (7 to 10 carbons) were more likely to induce changes in gene expression.