Showing 346-360 of 529
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Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort
Science
8 Jun 2021 | Environ Res
Childhood PFAS exposures may be associated with elevated serum lipid concentrations which can be a predictor of later development of hyperlipidemia and cardiovascular disease.
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Exploration of the developmental toxicity of TCS and PFOS to zebrafish embryos by whole-genome gene expression analyses
Science
1 Jun 2021 | Environ Sci Pollut Res Int
PFOS was found to disrupt normal organ development compared to triclosan.
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Evaluating the potential of KOH-modified composite biochar amendment to alleviate the ecotoxicity of perfluorooctanoic acid-contaminated sediment on Bellamya aeruginosa.
Science
25 May 2021 | Ecotoxicol Environ Saf
Both individual and combined PFAS could induce concentration-dependent cell toxicity and depletion of glutathione levels.
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Risk Assessment of Perfluorooctane Sulfonate (PFOS) using Dynamic Age Dependent Physiologically based Pharmacokinetic Model (PBPK) across human lifetime
Science
25 May 2021 | Environ Res
A model was developed to quantify the risk of PFOS throughout the human lifetime, particularly in susceptible age groups.
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Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
Science
25 May 2021 | Nat Commun
The AIM2 receptor in mice was found to reduce PFOS-induced inflammation, as well as tissue damage in the lungs, livers, and kidneys.
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Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women's health across the nation 1999-2018
Science
19 May 2021 | Int J Obes (Lond)
Certain PFAS were positively associated with greater body size and body fat and may be an underappreciated contributing factor to obesity risk.
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Maternal exposure of mice to sodium p-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring
Science
18 May 2021 | Endocr J
Exposure to PFAS was associated with endocrine disruption in mothers and their offspring.
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Exposure to legacy and novel perfluoroalkyl substance disturbs the metabolic homeostasis in pregnant women and fetuses: A metabolome-wide association study
Science
18 May 2021 | Environ Int
A total of 279 features in maternal serum and 338 features in cord serum were identified as metabolites associated with PFAS exposure.
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Study finds alarming levels of ‘forever chemicals’ in US mothers’ breast milk
News
13 May 2021 | The Guardian
The peer-reviewed study detected PFAS in all 50 samples tested with levels ranging from 50ppt to more than 1,850ppt.
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Serum concentrations of per−/polyfluoroalkyl substances and risk of type 2 diabetes: A case-control study
Science
4 May 2021 | Sci. Tot. Env.
PFHxS and PFHpA exposure were associated with an increased risk of developing type 2 diabetes.
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Interference of C6O4 on platelet aggregation pathways: Cues on the new-generation of perfluoro-alkyl substance
Science
4 May 2021 | Environ Int
A PFAS alternative, C6O4, was associated with an increased risk of cardiovascular events.
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Immunotoxicity of Per-and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure
Science
3 May 2021 | Toxics
Understudied PFAS have toxicological potential but require additional investigation across endpoints and species, including humans, to understand health effects via drinking water exposure.
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Bioactivity Profiling of Per- and Polyfluoroalkyl Substances (PFAS) Identifies Potential Toxicity Pathways Related to Molecular Structure
Science
28 Apr 2021 | Toxicology
Using 142 PFAS, key structural features were associated with receptor activity which can inform the design of new structures devoid of biological activity.
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Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Science
27 Apr 2021 | Crt. Rev. Tox.
This paper aims to present the main issues regarding the modulation of lipid homeostasis by the two most common PFASs, PFOS and PFOA, with emphasis on the underlying mechanisms relevant for humans.
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Life-course exposure to perfluoroalkyl substances in relation to markers of glucose homeostasis in early adulthood
Science
27 Apr 2021 | J Clin Endocrinol Metab
PFOS exposure was associated with decreased insulin sensitivity.