Dermal bioavailability of perfluoroalkyl substances using in vitro 3D human skin equivalent models
24 Jun 2024 | Environ. Int.
In vitro modeling showed substantial dermal absorption of PFAS, with around 50% of short-chain PFAS absorbing through the skin and less absorption of larger PFAS, suggesting that dermal exposure could be a significant source of exposure.
Beyond water: Solution-focused communication and regulation are required to address per- and poly-fluoroalkyl substances pollution
21 Jun 2024 | One Earth
Evidence-based science communication and additional policy interventions are urgently needed to address widespread PFAS pollution.
Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review
19 Jun 2024 | Curr Environ Health Rep
This review examines the connection between maternal exposure to PFAS and perinatal depression, identifying 23 common metabolic pathways, and recommends future research on specific metabolic processes and longitudinal study designs to better understand these associations.
Bioconcentration of per- and polyfluoroalkyl substances and precursors in fathead minnow tissues environmentally exposed to aqueous film-forming foam-contaminated waters
19 Jun 2024 | Environ Toxicol Chem
Fathead minnows exposed to PFAS-contaminated groundwater at Joint Base Cape Cod showed increasing PFAS levels in their tissues over time, indicating potential pathways for PFAS exposure in aquatic wildlife and humans.
Perfluoroalkyl substances in the meat of Polish farm animals and game - Occurrence, profiles and dietary intake
17 Jun 2024 | Sci Total Environ
Meat from farm animals and game was analyzed for PFAS contamination, revealing that wild boar meat had the highest levels, with potential health risks from frequent consumption, while meat from livestock and deer posed negligible health concerns in Poland.
In silico prediction of the interaction of legacy and novel per- and poly-fluoroalkyl substances (PFAS) with selected human transporters and of their possible accumulation in the human body
17 Jun 2024 | Arch Toxicol
PFAS were examined through computer simulations, revealing that legacy PFAS like PFOA and PFOS have a higher propensity to interact with human proteins involved in chemical transportation and accumulation, suggesting a greater potential for bioaccumulation compared to newer PFAS formulations.
Carry-over rate of per- and polyfluoroalkyl substances to raw milk and human exposure risks in different regions of China.
11 Jun 2024 | Sci Total Environ
The presence of PFAS in cow feed, drinking water, and raw milk across 20 regions in China reveals significant health risks, particularly for preschool children, due to the accumulation and transfer of these substances through milk consumption.
Occurrence of 80 Per and polyfluorinated alkyl substances (PFAS) in the Muscle and Liver tissues of Marine Mammals of the St. Lawrence Estuary and Gulf, Quebec, Canada
10 Jun 2024 | Front. Environ. Chem.
Marine mammals from the St. Lawrence Estuary and Gulf, such as dolphins and porpoises, were found to have high levels of PFAS in their tissues, with the white-sided dolphin showing the highest average concentrations—39 ng/g in muscle and 334 ng/g in liver—while species like the harp seal had much lower levels, emphasizing the need for stronger regulations to protect these vulnerable animals.
Occurrence of a "forever chemical" in the atmosphere above pristine Amazon Forest
10 Jun 2024 | Sci Total Environ
PFAS like PFOA were detected in the remote Amazon rainforest at concentrations up to 2 pg/m³, indicating long-range atmospheric transport from urban industrial sources and underscoring their widespread environmental impact.
Regulating “forever chemicals”: social data are necessary for the successful implementation of the essential use concept
8 Jun 2024 | Environ Sci Eur
Given the widespread persistence, mobility, and toxicity of many PFAS, a precautionary approach called the Essential Use Concept (EUC) is proposed, advocating for the phase-out of PFAS unless essential for health, safety, or critical societal functions. This paper discusses what broader societal perspectives are needed in the decision-making process to implement the EUC.
Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice
4 Jun 2024 | Sci Total Environ
PFOS not only disrupts lung development and increases asthma risk in mice, but also exacerbates allergic inflammation caused by house dust mites, particularly in females, underscoring potential sex-dependent health risks from PFOS exposure.
Association of co-exposure to organophosphate esters and per- and polyfluoroalkyl substances and mixture with cardiovascular-kidney-liver-metabolic biomarkers among Chinese adults
4 Jun 2024 | Ecotoxicol Environ Saf
Exposure to common environmental contaminants like organophosphate esters and PFAS, especially PFHxS and PFNA, is associated with disruptions in liver function and cholesterol levels, suggesting potential risks for chronic diseases due to their widespread presence in the human body.
Non-targeted analysis of per-and polyfluorinated substances in consumer food packaging
3 Jun 2024 | Chemosphere
A non-targeted workflow utilizing high-resolution mass spectrometry successfully detected previously unknown PFAS compounds in diverse consumer food packaging samples, revealing the presence of several compounds and emphasizing the prevalence of both emerging and legacy PFAS in food packaging materials.
The bioaccumulation and ecotoxicity of co-exposure of per(poly)fluoroalkyl substances and polystyrene microplastics to Eichhornia crassipes
3 Jun 2024 | Water Res
Gen X and F-53B, used as alternatives to PFOA and PFOS, respectively, show significant bioaccumulation and eco-environmental risks, especially when co-exposed with polystyrene microplastics, which increase their bioavailability and toxicity to the aquatic plant Eichhornia crassipes.
[Report] PFAS Management at Airports: A Guide
1 Jun 2024 | National Academy of Sciences
Developed as a guideline for airport personnel and aviation professionals, the summary underscores the challenges posed by PFAS contaminants in firefighting foams, highlighting the need to manage uncertainties in regulatory requirements, disposal practices, and health and safety measures while anticipating stricter standards for PFAS compounds.