Association of prenatal exposure to perfluorinated and polyfluoroalkyl substances with childhood neurodevelopment: A systematic review and meta-analysis
10 Jan 2024 | Ecotoxicol Environ Saf
A meta-analysis on prenatal exposure to PFAS suggests a sex-specific relationship, revealing that PFOS, PFOA, and PFHxS are associated with decreased performance IQ in boys but PFOS was linked to increased performance IQ in girls, while PFAS are linked to executive function impairments in children without a significant association with behavioral difficulties.
Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake
10 Jan 2024 | Toxics
This study exposed mice to a mixture of PFAS at levels equivalent to estimated daily human intake, revealing that even low concentrations of PFAS caused liver tissue changes and altered gene expression related to metabolism and cancer, emphasizing the need for thorough toxicity assessments of these persistent environmental contaminants.
Assessing potential human health and ecological implications of PFAS from leave-in dental products
3 Jan 2024 | Toxicol Ind Health
PFBA and PFOS were found in low levels in night guards with no detection in whitening trays, suggesting these dental products are unlikely to pose health concerns or contribute significantly to environmental PFAS exposure compared to exposure from food and water.
Binding of Per- and Polyfluoroalkyl Substances (PFAS) to Serum Proteins: Implications for Toxicokinetics in Humans
3 Jan 2024 | Environ Sci Technol
PFAS binding to major blood serum proteins is thought to affect toxicity, transport, and half-lives in the body. This study found shorter-chain PFAS showing a stronger binding to human serum albumin and longer-chain PFAS displaying a greater affinity for globulins, emphasizing the significance of understanding these interactions for more precise assessments of PFAS impact on human health in epidemiological studies.
Investigating the progression of preeclampsia through a comprehensive analysis of genes associated with per- and polyfluoroalkyl substances
2 Jan 2024 | Toxicol Mech Methods
Using advanced analysis of genetic data, researchers identified a potential link between PFAS and the risk of preeclampsia, suggesting that these environmental factors may play a role in the development of the disease, and highlighted six genes with diagnostic potential for preeclampsia.
Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics
30 Dec 2023 | Sci Total Environ
Exposure to PFOS may disrupt early skin development by altering cell morphology, gene expression, and crucial signaling pathways, suggesting a potential link between PFAS exposure and congenital skin diseases during embryonic development.
Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs
28 Dec 2023 | Environ Sci Technol
PFAS levels in the liver correlated well with other organs, supporting the use of blood concentrations as a measure of PFAS exposure and suggesting the liver as the primary organ of PFAS retention, with minor variations observed in other organs.
Prenatal per- and polyfluoroalkyl substances exposure and gut microbiota of infants: A prospective cohort study
28 Dec 2023 | Ecotoxicol Environ Saf
In a study of 69 mother-child pairs, PFAS was associated with changes in the gut microbiota of infants, potentially linking these alterations to known health impacts later in life.
Per-and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
27 Dec 2023 | CGH
A connection was found between elevated PFAS levels and increased odds of Crohn’s disease and ulcerative colitis for up to 10 years prior to diagnosis, with both legacy and emerging PFAS chemicals implicated.
GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways
27 Dec 2023 | Chem Res Toxicol
GenX, a substitute for PFOA, was found to cause liver damage and disrupt lipid metabolism in mice even at low environmental concentrations when exposed to drinking water.
Prenatal Exposure to Poly- and Perfluoroalkyl Substances (2009-2014) and Vaccine Antibody Titers of Measles, Mumps, Rubella, and Varicella in Children Four to Eight Years Old from the Healthy Start Cohort
26 Dec 2023 | Environ Health Perspect
Prenatal exposure to PFAS is linked to lower antibody levels in fully immunized children, particularly for measles and mumps, suggesting potential immunotoxic effects.
Invited Perspective. Per- and Polyfluoroalkyl Substances, Hepatotoxicity, and Liver Disease: Evidence and Clinical Responses
25 Dec 2023 | Medical Research Archives
This perspective outlines PFAS hepatoxicity, suggesting practical clinician responses to address patient and community needs, and emphasizing strong evidence of PFAS causing adverse changes in human liver biomarkers.
Comparison of the PFAS and physical-chemical parameter fluctuations between an ash landfill and a MSW landfill
22 Dec 2023 | Waste Manag
PFAS levels in municipal solid waste and incinerator ash landfillswere found to be higher in solid waste leachate, suggesting the importance of considering these differences when designing leachate management systems for different landfill types.
Firefighters' exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review.
18 Dec 2023 | Front Mater
The close link between firefighters and cancer may be partly driven by occupational exposure to carcinogenic PFAS found in turnout gear, firefighting foam, and fire station environments leading to elevated PFAS levels in firefighters’ blood serum.
First insights into per-and polyfluoroalkyl substance contamination in edible fish species of the Indus water system of Pakistan
17 Dec 2023 | Chemosphere
The study investigated the contamination of edible fish in major tributaries of the Indus System andfound high levels of PFAS, in certain fish species from areas with poor wastewater treatment in Pakistan, highlighting potential environmental and health concerns, and suggesting the need for ongoing monitoring and research into the bioaccumulation patterns of PFAS.