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• The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure

  Science

  8 Sep 2021 | Toxicology

  PFAS mixtures were found to have increased detrimental effects, especially when transferred from mother to offspring.

• Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain

  Science

  8 Sep 2021 | Environ Res

  PFAS, including short chains, were found inside the brain circumnavigating the blood-brain barrier.

• PFAS and potential adverse impacts on bone and adipose tissue through interactions with PPAR-gamma

  Science

  8 Sep 2021 | Endocrinology

  PFAS was found to affect cell differentiation and bone development in several human model species.

• Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids

  Science

  8 Sep 2021 | Toxicol Sci

  Longer-chain compounds (7 to 10 carbons) were more likely to induce changes in gene expression.

• Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco

  Science

  7 Sep 2021 | Environ Health

  Positive associations between PFAS and telomere length in women workers, with larger effects seen among firefighters as compared to office workers.

• Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha

  Science

  4 Sep 2021 | Environ Pollut

  Exposure to HFPO-DA induced developmental cardio-toxicity and hepatotoxicity in hatchling chickens similar to PFOA

• The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid

  Science

  2 Sep 2021 | Chemosphere

  PFBS exposures were found to alter egg and embryo development, when exposure occurs preconception.

• Per/polyfluoroalkyl substances production, applications and environmental impacts

  Science

  31 Aug 2021 | Bioresource Tech.

  Current chemical and biological remediation technologies are expensive/not effective and thus new remediation technologies must be developed.

• Toxic ‘Forever Chemicals’ Contaminate Indoor Air at Worrying Levels, Study Finds

  News

  31 Aug 2021 | The Guardian

  Food and water were thought to be the main ways humans are exposed to PFAS, but the study findings suggest that breathing probably represents a third significant exposure route.

• Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice

  Science

  31 Aug 2021 | Environ Sci Technol

  The inhibition of nutrient absorption may be a prominent adverse effect induced by exposure to GenX, its analogs, and PFOA.

• Analysis of per- and poly-fluoroalkyl substances (PFAS) in processed foods from FDA's Total Diet Study

  Science

  31 Aug 2021 | Anal Bioanal Chem

  PFAS features detected by LC-MS/MS correlated well in abundance with LC-IMS-MS data; however, LC-IMS-MS identified a number of additional PFAS, many known to be components of firefighting foams.

• Early pregnancy loss: Do Per- and polyfluoroalkyl substances matter?

  Science

  31 Aug 2021 | Environ Int

  Overall, we suggest that most PFAS were not associated with early pregnancy loss at the current exposure levels.

• Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice

  Science

  31 Aug 2021 | Environ Pollut

  Potential gut toxicity of HFPO-DA and is perceived as a major problem of health risk that affects inflammation, gut barrier dysfunction, and gut microbiota disturbance in mammals.

• Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort

  Science

  31 Aug 2021 | Environ Res

  Childhood concentrations of PFASs were associated with decreased regulation of appetite and fat storage.

• Rapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE-UPLC-MS/MS

  Science

  31 Aug 2021 | Toxics

  A new analytical method was optimized for use on mammalian tissues with up to 89% detection.