Showing 2326-2340 of 3558
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Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
Science
8 Sep 2021 | Environ Int
Exposure of mice to a mixture of PFAS results in abnormal modulation of cholesterol levels leading to increased liver weight and inflammation.
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Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model
Science
8 Sep 2021 | Food Chem Toxicol
Sustained dermal exposure to PFBA induces liver toxicity and raises concerns of short-chain PFAS being promoted as safer alternatives.
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Potency ranking of per- and polyfluoroalkyl substances using high-throughput transcriptomic analysis of human liver spheroids
Science
8 Sep 2021 | Toxicol Sci
Longer-chain compounds (7 to 10 carbons) were more likely to induce changes in gene expression.
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Use of glioma to assess the distribution of patterns of perfluoroalkyl and polyfluoroalkyl substances in human brain
Science
8 Sep 2021 | Environ Res
PFAS, including short chains, were found inside the brain circumnavigating the blood-brain barrier.
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The role of maternal high fat diet on mouse pup metabolic endpoints following perinatal PFAS and PFAS mixture exposure
Science
8 Sep 2021 | Toxicology
PFAS mixtures were found to have increased detrimental effects, especially when transferred from mother to offspring.
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Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
Science
7 Sep 2021 | Environ Health
Positive associations between PFAS and telomere length in women workers, with larger effects seen among firefighters as compared to office workers.
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Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha
Science
4 Sep 2021 | Environ Pollut
Exposure to HFPO-DA induced developmental cardio-toxicity and hepatotoxicity in hatchling chickens similar to PFOA
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The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid
Science
2 Sep 2021 | Chemosphere
PFBS exposures were found to alter egg and embryo development, when exposure occurs preconception.
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Per/polyfluoroalkyl substances production, applications and environmental impacts
Science
31 Aug 2021 | Bioresource Tech.
Current chemical and biological remediation technologies are expensive/not effective and thus new remediation technologies must be developed.
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Toxic ‘Forever Chemicals’ Contaminate Indoor Air at Worrying Levels, Study Finds
News
31 Aug 2021 | The Guardian
Food and water were thought to be the main ways humans are exposed to PFAS, but the study findings suggest that breathing probably represents a third significant exposure route.
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Rapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE-UPLC-MS/MS
Science
31 Aug 2021 | Toxics
A new analytical method was optimized for use on mammalian tissues with up to 89% detection.
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Understanding the Impact of Perfluorinated Compounds on Cardiovascular Diseases and Their Risk Factors: A Meta-Analysis Study
Science
31 Aug 2021 | Int J Environ Res Public Health
PFOA and PFOS were positively associated with developing cardiovascular diseases and their risk factors.
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Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice
Science
31 Aug 2021 | Environ Sci Technol
The inhibition of nutrient absorption may be a prominent adverse effect induced by exposure to GenX, its analogs, and PFOA.
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Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort
Science
31 Aug 2021 | Environ Res
Childhood concentrations of PFASs were associated with decreased regulation of appetite and fat storage.
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Early pregnancy loss: Do Per- and polyfluoroalkyl substances matter?
Science
31 Aug 2021 | Environ Int
Overall, we suggest that most PFAS were not associated with early pregnancy loss at the current exposure levels.